摘要
背景:哺乳动物的胚胎期造血包括原始造血和永久造血。原始造血发生于卵黄囊已被普遍认可,但永久造血的起源部位一直是造血领域争论的焦点。目的:探索永久造血的胚胎起源。方法:第一作者应用计算机检索 2000-01/2010-03 PubMed 数据库相关文章,检索词为"hematopoietic stem cell,hematopoiesis,yolk sac,AGM region ",同时检索 2000-01/2010-03 CNKI 数据库相关文章,检索词为"造血干细胞,造血,卵黄囊,AGM 区"。共检索到文献 682 篇,排除重复性研究,最终纳入 42 篇。结果与结论:传统观点认为永久造血起源于胚外卵黄囊,但近些年的一系列研究表明永久造血首先起源于胚内 AGM 区。胎盘是新近发现的从主动脉-性腺-中肾(AGM)区到胎肝阶段可能生成造血细胞的部位。在卵黄囊和 PSp/AGM 区中,造血细胞的祖细胞分别表现为两种不同的模式:在卵黄囊中,造血细胞和内皮细胞共同来源于成血血管细胞;在主动脉-性腺-中肾区中,背主动脉腹侧壁的生血内皮生成造血干细胞。此外,造血发育过程受多个信号通路的调节。
BACKGROUND：The process consists of primitive hematopoiesis and definitive hematopoiesis in mammalian.It has been approved that primitive hematopoiesis emergence from yolk sac.However, the original sites of definitive hematopoiesis have been a controversial issue in the field of hematopoiesis.OBJECTIVE：To explore embryonic origins of definitive hematopoiesis.METHODS：The first author retrieved PubMed database for articles published from January 2000 to March 2010.The key wrds were ＂hematopoietic stem cell, hematopoiesis, yolk sac, aorta-gonad-mesonephros （AGM） region＂.Simultaneously, China National Knowledge Infrastructure database was also retrieved for relevant articles published from January 2000 to March 2010.The key wrds were ＂hematopoietic stem cell, hematopoiesis, yolk sac, AGM region＂.A total of 682 articles were obtained, and the literature of repetitive content was excluded.Finally, 42 articles were included.RESULTS AND CONCLUSION：Traditional opinions thought the definitive hematopoiesis origins from yolk sac of extra-embryo.However, a series of studies showed that the definitive hematopoiesis come from AGM region of intra-embryo first.The placenta is a newly discovered site which may generate hematopoietic cells during period from AGM region to fetal liver.In the yolk sac and PSp/AGM region, the progenitor cell of hematopoietic cell presents two different models.The hematopoietic cells and endothelial cells are normally derived from the hemangioblast in the yolk sac.However, in the AGM region, hematopoietic stem cells come from haemogenic endothelium of the dorsal aorta ventral wall.In addition, hematopoitic development process is regulated by several signal pathways.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2010年第36期6821-6824,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
