摘要
目的:综述生物材料治疗韧带缺损中表面修饰的主要方法及其效果,为科研工作者提供一定的借鉴。方法:采用电子检索的方式,在万方数据库(http://www.wanfangdata.com.cn/)中检索2000-01/2010-05关于韧带重建生物材料表面修饰方法与应用效果的研究文章,关键词为"生物材料,表面修饰,人工韧带"。排除重复研究、普通综述或Meta分析类文章,筛选纳入22篇文献进行评价。结果:目前为了使生物材料在治疗韧带、肌腱等缺损中具有良好的生物相容性和细胞亲和性,要进行生物材料表面改性,通常称为表面修饰。所采用的表面修饰方法主要有固定蛋白质法、固定多肽法、辐射接枝法、离子注入法。研究表明,通过生物材料表面修饰,不仅增进了细胞的黏附,而且促进了细胞的增殖。结论:生物材料的表面修饰是一个复杂的系统工程,需要兼顾材料科学和生物科学的需要,实现优化。理想的表面修饰应该兼顾表面拓扑结构、特异性识别、亲水/疏水平衡、蛋白质吸附等各个方面才能得到功能化的新生组织。
OBJECTIVE：To review the approaches and therapeutic effects of surface modification of ligament defects treatment using biomaterial,and to provide a reference for the researchers.METHODS：A computer search of Wanfang database （http：//www.wanfangdata.com.cn/） from January 2000 to May 2010 was performed for articles about the surface modification methods and application of the biomaterials for ligament reconstruction,using Key words of ＂biological materials,surface modification,artificial ligaments＂ in Chinese.The repeated study,general review or Meta analysis articles were excluded,22 articles were screened into the evaluation.RESULTS：In order to make biomaterials present good biocompatibility and cell affinity in the treatment of ligament,tendon and other defects,the biomaterials should be surface modified,commonly named surface modification.The surface modification methods include fixed protein,fixed peptide,radiation grafting,ion implantation methods.Through biomaterial surface modification,cell adhesion is not only enhanced,but cell proliferation is promoted.CONCLUSION：The surface modification of biomaterials is a complex system engineering,which requires to consider materials science and bioscience needs,thus achieving optimization.Ideal surface modification should take the surface topology,specific recognition,hydrophilic/hydrophobic balance,protein adsorption into account,therefore functional new tissues can be obained.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2010年第38期7161-7164,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
