摘要
目的:探讨炎症因子和细胞因子水平预测冠状动脉支架后再狭窄的意义。方法:以"涂层冠状动脉支架,再狭窄,生物相容性,炎症因子,细胞因子"为关键词,采用计算机检索中国CNKI学术文献总库2000-01/2009-12相关文章。纳入冠状动脉支架后炎症因子和细胞因子水平与再狭窄的文章,排除重复研究或Meta分析类文章,共入选16篇文章进行分析。结果:冠状动脉内支架置入有可能会引起冠状动脉血管的损伤,促进体内细胞释放炎症因子。收集的资料表明,支架置入后外周血C-反应蛋白、白细胞介素、肿瘤坏死因子α和γ-干扰素等炎症因子和细胞因子有明显的表达,能很好的反映支架置入后局部血管损伤程度和炎症水平及应用支架的生物相容性。结论:检测外周血炎性因子和细胞因子对支架内再狭窄有一定的预测性价值,还能在一定程度上能反映其他部位粥样斑块的稳定情况,可作为支架置入后冠心病二级预防的可行临床观测指标。
OBJECTIVE：To investigate the significance of inflammatory factors and cytokine levels to predict coronary stent restenosis.METHODS：Using ＂coated coronary stent,restenosis,biocompatibility,inflammatory factor,cytokines＂ in Chinese as the Key words,a computer search of Chinese CNKI Academic Database from January 2000 to December 2009 was performed.Articles related to inflammatory factors and cytokine levels in restenosis after coronary stenting were included,while repeated study or Mata analysis articles were excluded,16 articles were selected for analysis.RESULTS：Coronary stent implantation may lead to coronary artery injury,and promote in vivo cells to release inflammatory factors.After stent implantation,C-reactive protein,interleukin,tumor necrosis factor α and γ-interferon and other inflammatory factors and cytokines in peripheral blood have distinct expression,can reflect the local vascular injury and inflammation,as well as the applied stent biocompatibility after stenting.CONCLUSION：The detection of inflammatory factors and cytokines in peripheral blood have predictive value on the in-stent restenosis,also reflect the stability of the atherosclerotic plaque in other parts,as feasible clinical observation index for the second level of coronary heart disease prevention after stenting.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2010年第38期7185-7188,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
