摘要
目的:观察以顺铂为主的PVP诱导化疗结合根治性手术的综合治疗方法,治疗764例口腔黏膜鳞状细胞癌患者的近期和中远期疗效,并对其不良反应进行分析。方法:1986—2005年治疗的764例患者,均经组织病理学证实为口腔黏膜鳞状细胞癌,并接受一个疗程的PVP方案,配合水化利尿、止吐、抗过敏等辅助治疗;化疗21 d左右评定疗效后,施行原发癌肿瘤扩大切除的联合根治术。结果:近期疗效,完全缓解(CR)119例,部分缓解(PR) 542例,无变化(NC)103例,总有效率(RR)为86.51%(661/764);中远期疗效,1、3、5年生存率分别为92.93%、69.37%和68.84%。死亡高峰位于术后12～24个月,毒副反应未影响本疗法的进行。结论:以顺铂为主的PVP诱导化疗方案对口腔鳞癌的综合治疗有良好的应用价值。
Objective： To observe the short and long term effects of preoperative inductive combined chemotherapy with eisplatin in the treatments of oral squamous carcinoma. Methods： PVP combined chemotherapy was used in 764 cases （1986-2005） with oral squamous carcinoma. When chemotherapy finished at the 21~ day before operation, the short term curative effect was evaluated. Results： The short term curative rate of PVP in case was 86.51%. 1,3 and 5-year survival rate were 92.93%,69.37%,68.84%. The dead peak was found at 12-24 months, and ended at the 36th month. Conclusion： The preoperative inductive combined chemotherapy with PVP is feasible for the treatment of oral squamous carcinoma.
出处
《口腔颌面外科杂志》
CAS
2010年第5期331-333,共3页
Journal of Oral and Maxillofacial Surgery
基金
安徽省医学科研课题计划项目(09A058)
关键词
口腔鳞癌
PVP方案
诱导化疗
中远期生存率
oral squamous cell carcinoma
PVP preoperative inductive chemotherapy
curative effect
long term survival rate
