期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

外周血CD4^＋T细胞的ATP含量与肝移植后早期感染的相关性 被引量：6

Relationship of ATP contents in peripheral blood CD4^+T lymphocytes with early infection after liver transplantation
原文传递
导出
摘要 目的探讨CD4+T细胞的ATP含量与肝移植术后早期(术后1个月内)感染的相关性。方法采集85例肝移植患者、60名健康志愿者(对照组)的全血标本,术前、术后1、2、4周及感染当日和经治疗后体温正常3d各1份;用Immu-KnowTM免疫细胞功能测定试剂盒检测CD4+T细胞的ATP值。结果感染组ATP值在术前较低,术后第1周达到低谷,显著低于同期非感染组(P<0.01)。经ROC曲线分析,术后第1周的低ATP值对诊断肝移植术后感染具有较好的敏感度和特异度;当截断值为161μg/L时,其诊断感染的敏感度为85%,特异度为91%。感染当日的ATP含量降低与感染具有良好的相关性,经抗感染治疗体温正常3d后,其ATP值较感染当日明显升高(P<0.01)。结论肝移植术后早期CD4+T细胞的ATP值动态变化与肝移植术后感染具有良好的相关性,监测肝移植术后患者该指标对评估其免疫状态、预防和诊治感染具有一定价值。
作者 董家勇 李瑞东 殷浩 郭闻渊 林峰 邹游 张晓军 吴幼民 丁国善 傅志仁 王正昕
机构地区 第二军医大学长征医院器官移植科 University of Arkansas for Medical Sciences(UAMS)
出处 《第二军医大学学报》 CAS CSCD 北大核心 2010年第10期1146-1148,共3页 Academic Journal of Second Military Medical University
基金 国家科技支撑计划课题(2008BAI60B03) 上海市科委科研计划项目(08410701100)~~
关键词 肝移植 感染 CD4^+T淋巴细胞 三磷酸腺苷
分类号 R657.3 [医药卫生—外科学]
  • 相关文献

参考文献13

  • 1Tippner C, Nashan B, Hoshino K, Schmidt-Sandte E, Akimaru K,B/Sker K H,et al. Clinical and subclinical acute rejection ear ly after liver transplantation: contributing factors and relevance for the long-term course[J]. Transplantation, 2001,72:1122 -1128.
  • 2Israeli M,Klein T,Sredni B,Avitzur Y,Mor E,Bar Nathen N, et al. ImmuKnow: a new parameter in immune monitoring of pediatric liver transplantation recipients [J]. Liver Transpl, 2008,14:893 -898.
  • 3Israeli M, Yussim A, Mor E, Sredni B, Klein T. Preceeding the rejection: in search for a comprehensive post transplant immune monitoring platform [J]. Transpl Immunol, 2007,18:7 -12.
  • 4医院感染诊断标准(试行)[J].中华医学杂志,2001,81(5):314-320. 被引量：5940
  • 5Singh N. Infectious diseases in the liver transplant recipient[J]. Semin Gastrointest Dis,1998,9:136 -146.
  • 6Wade J J,Rolando N, Hayllar K,Philpott-Howard J,Casewell M W, Williams R. Bacterial and fungal infections after liver transplantation: an analysis of 284 patients[J]. Hepatology, 1995,21:1328 -1336.
  • 7Venkataramanan R, Shaw L M, Sarkozi L, Mullins R, Pirsch J, MacFarlane G, et al. Clinical utility of monitoring tacrolimus blood concentrations in liver transplant patients [J]. J Clin Pharmacol, 2001,41 : 542-551.
  • 8Rovira P, Mascarell L, Truffa Bachi P. The impact of immunosuppressive drugs on the analysis of T cell activation[J]. Curr Med Chem,2000,7:673- 692.
  • 9Hooper E,Hawkins D M,Kowalski R J,Post D R,Brilz J A, Brooks K C, et ah Establishing pediatric immune response zones using the Cylex ImmuKnow assay[J]. Clin Transplant, 2005,19:834- 839.
  • 10Kowalski R, Post D, Schneider M C, Britz J, Thomas J, Deierhoi M,et al. Immune cell function testing: an adjunct to therapeutic drug monitoring in transplant patient management[J]. Clin Transplant,2003,17 : 77 88.

二级参考文献17

  • 1Silveira FP,Husain S.Fungal infections in solid organ transplantation.Med Mycol,2007,45(4):305-320.
  • 2Cruciani M,Mengoli C,Malena M,et al.Antifungal prophylaxis in liver transplant patients:a systematic review and meta-analysis.Liver Transpl,2006,12(5):850-858.
  • 3Reed A,Herndon JB,Ersoz N,et al.Effect of prophylaxis on fungal infection and costs for high-risk liver transplant recipients.Liver Transpl,2007,13(12):1743-1750.
  • 4Rabkin JM,Oroloff SL,Corless CL,et al.Association of fungal infection and increased mortality in liver transplant recipients.Am J Surg,2000,4179(5):426-430.
  • 5Fung JJ.Fungal infection in liver transplantation.Transpl Infect Dis,2002,4 Suppl 3:S18-23.
  • 6Adam R,McMaster P,O'Grady JG,et al.Evolution of liver transplantation in Europe:report of the European Liver Transplant Registry.Liver Transpl,2003,9(12):1231-1243.
  • 7Oner-Ey(u)bo(g)lu F,Karacan O,Akcay S,et al.Invasive pulmonary fungal infections in solid organ transplant recipients:a four-year review.Transplant Proc,2003,35(7):2689-2691.
  • 8Patel R,Portela D,Badley AD,et al.Risk factors of invasive Candida and non-Candida fungal infections after liver transplantation.Transplantation,1996,62(7):926-934.
  • 9Garbino J,Romand JA,Pittet D,et al.Infection and rejection in liver transplant patients:a 10-year Swiss single-centre experience.Swiss Med Wkly,2005,135(39-40):587-593.
  • 10Sharpe MD,Ghent C,Grant D,et al.Efficacy and safety of itraconazole prophylaxis for fungal infections after orthotopic liver transplantation:a prospective,randomized,double-blind study.Transplantation,2003,76(6):977-983.

共引文献5944

同被引文献68

引证文献6

二级引证文献103

第二军医大学学报
2010年 第10期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部