摘要
目的总结2004年9月～2009年8月在该所治疗的肺结核病人发生药物性肝损伤108例,对其临床特点进行分析并探讨最佳治疗措施。方法对于ALT 150 U以下的无临床症状者继续抗结核治疗,同时保肝降酶治疗,密切监测肝功能;对有明显肝损伤临床症状而且ALT在150 U以上的患者应立即停用对肝脏损伤大的抗结核药物,治疗肝损伤,监测肝功能,肝损伤减轻后再行抗结核治疗并继续监测肝功能。结果本组108例全部恢复正常。结论抗结核治疗药物可引起严重肝损伤,需要积极防治及早发现并处理,轻度病人在保肝治疗同时可以抗结核治疗,以完成疗程,确保抗结核疗效。
【Objective】 To summarize drug-induced liver diseases in the treatment of 108 cases of tuberculosis in our institute from September 2004 to August 2009 by analyzing the clinical features in order to find the best treatment.【Methods】Tuberculosis patients with no clinical symptoms of drug-induced liver disease whose ALT level was under 150 units continued to receive anti-tuberculosis treatment and simultaneous liver protection and en-zyme control drugs and their liver function was monitored closely.Tuberculosis patients with serious drug-induced liver disease whose ALT level was over 150 units were treated with hepatic drugs first rather than anti-tuberculosis drugs until their liver function recovered according to monitored data.【Result】108 cases of tuberculoses patients are cured.【Conclusion】Serious liver damage can be caused by anti-tuberculosis drugs,which should be diagnosed and treated early.Patients with no clear drug-induced liver damage can be treated with anti-tuberculosis drugs to ensure the effectiveness of treatment.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2010年第18期2868-2869,共2页
China Journal of Modern Medicine
关键词
药物治疗
肝损伤
抗结核药
drug treatment
liver injury
anti-tuberculosis drugs
