摘要
目的探讨p27和cyclinE的表达与胃肠道间质瘤(GIST)临床病理学特征的关系及其相关性。方法应用免疫组化SP法观察40例胃肠道间质瘤中p27和cyclinE的表达情况。结果 40例GIST中有22例表达p27,24例表达cyclinE,阳性表达率分别为55.0%和60.0%。p27和cyclinE的表达与GIST的部位、组织学分型、肿瘤大小无关(P>0.05)。与组织学分级有关(P<0.05),p27和cyclinE的表达具有负相关性(r=-0.386,P=0.002)。结论 p27和cyclinE在胃肠道间质瘤的发生、发展中发挥作用,两者可作为判断良恶性的客观指标。
Objective To investigate the relationship between the expression of p27,cyclinE and clinicopathologic characteristics in gastrointestinal stromal tumor（ GIST）. Methods Immunohistochemical SP was used to investigate p27 and cyclinE expression in 40 cases of GIST. Results Among 40 cases of GIST, 22 cases were positive for p27 （ 55.0% ） , 24 cases for cyelinE（ 60.0% ）. The expression of p27 and cyclinE had no correlation with loealisation, histological subtype, tumor size of GIST（ P 〉 0.05 ） , and had correlation with histological grade （P 〈 0.05）. p27 expression had negative correlation with cyclinE expression （ r = - 0. 386, P = 0. 002）. Conclusion The expression of p27 and cyclinE plays an important role in the pathogenesis and development of GIST, which may be used as an objective parameter for distinguishing maligant from benign GIST.
出处
《医学研究杂志》
2010年第10期60-62,共3页
Journal of Medical Research
基金
黑龙江省教育厅科学技术研究项目(11513118)
