摘要
目的:探讨自拟疏肝解郁汤治疗腹泻型肠易激综合征(diarrhea-predominant irritable bowel syndrome,IBS-D)的疗效.方法:将60例患者随机分成2组,黛力新组予以黛力新片,每次1片,早晨和中午各1次口服,总疗程为8wk;中药治疗组:每日1剂,每剂2煎,分早晚温服,总疗程为8wk.治疗前后分别进行焦虑自评量表(SAS)和抑郁自评量表(SDS)评分及IBS-D症状评分,选择治疗前后自身配对t检验判断治疗效果.结果:IBS-D患者治疗前SAS和SDS评分显著高于健康对照组(55.6±11.8vs31.9±5.6,57.2±10.3vs33.0±6.4,均P<0.05);治疗8wk后,黛力新组和中药治疗组SAS、SDS评分及IBS症状评分均显著好转(43.0±7.2vs56.5±11.4,47.2±6.5vs57.6±10.2,5.7±3.9vs11.6±3.8;45.3±8.7vs54.6±12.2,47.6±6.1vs56.9±10.6,6.5±3.6vs11.9±4.0,均P<0.05),且两组间无统计学差异;但黛力新组不良反应发生率高于中药组.结论:黛力新和疏肝解郁汤均能改善患者焦虑、抑郁情绪,治疗IBS-D疗效显著,但中药治疗不良反应少,利于推广.
AIM：To evaluate the efficacy of Shuganjieyu Decoction in the treatment of patients with diarrhea-predominant irritable bowel syndrome（IBS-D） and to compare with that of Deanxit.METHODS：Sixty IBS-D patients were randomly divided into two groups：Deanxit group and Chinese medicine treatment（CM） group.The treatment lasted for 8 wk.The CM group was treated with Shuganjieyu Decoction,while the Deanxit group was treated with Deanxit.Before and after the treatment,the scores of self-rating anxiety scale（SAS）,self-rating depression scale（SDS）,and IBS symptoms were analyzed.RESULTS：The SAS and SDS scores were significantly higher in IBS-D patients than in healthy controls（55.6 ± 11.8 vs 31.9 ± 5.6 and 57.2 ± 10.3 vs 33.0 ± 6.4,both P 0.05）.After 8 wk of treatment,the scores of SAS,SDS,and IBS symptoms were significantly improved in the Deanxit group and CM group compared with untreated patients（Deanxit group：43.0 ± 7.2 vs 56.5 ± 11.4,47.2 ± 6.5 vs 57.6 ± 10.2,5.7 ± 3.9 vs 11.6 ± 3.8;CM group：45.3 ± 8.7 vs 54.6 ± 12.2,47.6 ± 6.1 vs 56.9 ± 10.6,6.5 ± 3.6 vs 11.9 ± 4.0,all P 0.05） though no signif icant difference was noted between the Deanxit group and CM group.The rate of adverse reactions was lower in the CM group than in the Deanxit group.CONCLUSION：Both Deanxit and Shuganjieyu Decoction are effective in the treatment of IBS-D patients.Shuganjieyu Decoction is associated with less adverse reactions than Deanxit.
出处
《世界华人消化杂志》
CAS
北大核心
2010年第25期2715-2718,共4页
World Chinese Journal of Digestology
关键词
肠易激综合征
黛力新
疏肝解郁汤
疗效
Irritable bowel syndrome
Deanxit
Shuganjieyu Decoction
Efficacy
