摘要
目的:了解中药复方在煎煮过程中化学成分相互作用的研究现状。方法:查阅近期的相关研究文献,通过对其中部分研究成果进行归类,总结中药复方配伍在煎煮过程中化学成分之间的相互影响,及其研究方法。结果:目前采用的研究方法主要包括:植物化学方法、色谱分析方法、质谱分析方法、色谱质谱分析方法等。与单味药材煎煮(单煎)相比,合煎(复方煎剂)的化学成分发生的变化,总结起来包括有以下4个方面:(1)复方汤剂的化学成分与药材单煎的汤剂基本保持一致;(2)复方汤剂的某些化学成分与药材单煎的汤剂相比含量升高;(3)复方汤剂的某些化学成分与药材单煎的汤剂相比含量降低;(4)复方汤剂的化学成分在煎煮过程中发生化学成分转化,产生新的物质。结论:方剂配伍对复方的化学成分确实存在一定的影响,导致复方汤剂中化学组分的含量,或种类的变化,这种变化可能是中药复方配伍的协同作用的物质基础之一。目前,进行方剂配伍的化学机制的研究还不够系统,方法还不够完善,采用色谱质谱联用技术,对方剂配伍和单味药材进行全成分比较,可能是研究方剂配伍的化学机制的有效方法之一。
The interactions among different chemicals from herbs of Traditional Chinese Medicine （TCM） compounds in the process of decocting were described in this review. The experiment methods employed for this aim were also reviewed. The chemical interactions among the compositions of TCM compounds were divided into 4 cases according to previous studies in near recent. By compared to the decoction of a signal herb, （1） the constituents from different herb did not interact with each other during the process, （2） the quantities of some chemicals in the decoction in- creased, （3） the quantities of some chemicals in the decoction decreased, （4） new compounds were derived from the chemical reactions during the decocting process. The main methods employed in these studies can be described from 4 aspects： phyto-chemical, chromatographic, mass spectrometry, and chromatography - mass spectrometry methods. In conclusion, the chemical interactions in the process of decocting may change the chemical composition of a TCM compound. This might be the substantial basis of the compatibility of herbs, and also the reason that formulation changes the clinical application of an herb. Accumulation of data is needed to explain the underlying mechanism of the compatibility of herbs, and how formulation changes the clinical application of an herb.
出处
《世界科学技术-中医药现代化》
2010年第5期699-707,共9页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
北京理工大学教育专项基础研究项目(20091624014):人血清白蛋白非酶糖基化反应动态模式的研究
负责人:肖盛元
科学技术部国家科技支撑计划项目(2007BAI38B03-06):人参
五味子等大宗药材炮制加工新工艺研究及系列功能产品开发--人参炮制组织切片pH成像装置的研制
负责人:肖盛元
关键词
中药复方
配伍
煎煮过程
Chinese herb compound, Chemical interaction, Decoction
