摘要
目的:了解23种人乳头瘤病毒(Human papillo maviruses,HPV)型别在永川地区人群中的感染情况及分布特点,为本地区人乳头瘤病毒感染诊断及其相关疾病的防治提供重要依据。方法:应用基于反向膜杂交的基因芯片技术对665例临床送检标本进行分型检测,所得数据用SPSS等软件进行统计分析。结果:HPV总感染率为37.65%,23种基因型检出20种,其中单一型别感染率为27.25%,两型混合感染率为7.22%,3型(包括3型)以上混合感染率为3.18%。HPV亚型分布情况为:HPV16型9.92%、HPV6型5.74%、HPV11型4.36%、HPV33型1.32%、HPV58型1.05%、HPV43型1.02%、HPV18型0.75%,其余型别3.29%;高危型HPV在≤20、21～30、31～40、>40年龄组的感染率依次为14.1%、15.2%、17.2%、17.3%(χ2=3.0,P>0.05),组间比较差异无显著性;低危型HPV在各年龄组的感染率依次为20.3%、11.7%、10.1%、10.1%(χ2=23.28,P<0.01),组间比较差异具有显著性。结论:本地区人群HPV感染率较高,且以单一亚型感染为主,其中HPV16为高危型HPV感染主要的型别,低危型HPV感染以HPV6和HPV11为主;HPV各型别的感染率与年龄有一定的关系,该结果为防治宫颈癌、尖锐湿疣等其它HPV相关疾病提供了理论依据。
Objective：To comprehend the status of infection as well as distribution of types of Human papillomaviruses（HPV） and provide evidence for diagnosis and prevention.Methods：665 samples were detected and genotyped with the technology of gene chips.The data was analyzed with the statistical software SPSS13.0.Results：①37.65% of those samples were detected positive for HPV infection and 20 HPV genotypes were detected successfully.Among them,27.25% were infected by single HPV genotype,7.22% were infected by two genotypes and 3.18% were infected by three genotypes.In the single infection of HPV,the percentages of 16,6,11,33,58,43,18 were 9.92%,5.74%,4.36%,1.32%,1.05%,1.02%,0.75% respectively,and the rate of others of other genotypes were 3.29%.②The rates of different age group of high risk HPV were 14.1%（≤20）,15.2%（21～30）,17.2%（31～40）,17.3%（40）（χ2=3.0,P0.05）.The rates of different age group of low risk HPV were 20.3%（≤20）,11.7%（21～30）,10.1%（31～40）,10.1%（40）（χ2=23.28,P0.01）,a statistically significant difference between the groups.Conclusion：①In the area of Sichuan,HPV infection situation was comparatively severe and most were single infection.Among the high risk HPV infections,HPV16 prevalence was highest,and among the low risk HPV infections,types 6 and 11 were the most prevalent.②Age had certain something to do with HPV infection.③The present study palyed an important role in preventing and treating the diseases caused by HPV,such as cervical cancer,condylomata acuminate.
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2010年第9期1407-1410,共4页
Journal of Chongqing Medical University
关键词
人乳头瘤病毒
型别分布
宫颈癌
尖锐湿疣
Human papillomaviruses
Types distribution
Cervical cancer
Condylomata acuminate
