期刊文献+

胱抑素C及CGFR评价慢性肾脏病肾功能的临床意义 被引量:12

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摘要 目的:本文测定各期慢性肾脏病(CKD)患者的胱抑素C与血清肌酐(Scr),分析二者异常表达率,并探讨依据CysC计算的CGFR与MDRD公式计算的eGFR的相关性,寻找方便、灵敏、准确评价肾功能的指标。方法:将172例CKD患者依据MDRD公式计算的eGFR进行分期(美国NKF-K/DOQI指南),分别测定各期患者的Scr、血清尿素氮(BUN)、血清白蛋白(Alb)、胱抑素C(Cys C),计算CGFR,分析CysC与Scr的异常表达率及CGFR与eGFR的相关性。结果:CKDⅠ期组患者Cys C和Scr诊断肾功能异常的敏感性分别为21.88%和0%,CKDⅡ期组分别为65%和15%,CKDⅢ期组分别为86.84%和97.37%,Ⅳ期与Ⅴ期组患者血清Cys C异常表达率与Scr相同,均达到100%。在各期CKD中,CGFR与eGFR均具有显著相关性(P<0.01)。结论:CKD各期患者CGFR和eGFR密切相关,CGFR评估肾小球滤过率与MDRD计算评估的结果相符,CGFR与eGFR在判断肾功能方面具有一致性。而在CKDⅠ、Ⅱ、Ⅲ期患者血清Cys C异常表达率高于Scr,提示在肾功能损害早中期血清Cys C比Scr更敏感。Cys C及CGFR是评价肾功能的方便、灵敏、可靠的指标。
出处 《中国中西医结合肾病杂志》 2010年第9期807-809,共3页 Chinese Journal of Integrated Traditional and Western Nephrology
基金 上海市卫生局基金资助项目(No.2008224)
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参考文献7

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共引文献84

同被引文献87

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