摘要
目的:探讨冠心病及Ⅱ型糖尿病并发冠心病患者血清脂联素水平的变化及临床意义。方法:用酶联免疫法分别测定101例冠心病患者和33例非冠心病患者、86例冠脉造影阳性患者和15例冠脉造影阴性患者的血清脂联素水平,及糖尿病或糖耐量受损患者中,54例并发冠心病者和13例未并发冠心病者的血清脂联素水平。结果:冠心病和冠脉造影阳性患者的血清脂联素水平分别为3.9985±0.2147mg/L和3.9192±0.2182mg/L,糖尿病或糖耐量受损并发冠心病患者的血清脂联素水平为3.9582±0.1868mg/L,均较相应对照组下降(P<0.05)。结论:血清脂联素水平下降可能作为冠心病辅助诊断和病变严重程度的新指标,同时,它也可能成为糖尿病是否并发冠心病的新预测指标,有潜在的临床应用价值。
Objective：To investigate the changes of serum adiponectin concentrations and clinical role in patients with coronary heart diseases（CHD） and type 2 diabetes/ impaired glucose metabolism complicating CHD.Method：The serum adiponectin was measured in 101 patients with CHD and 33 patients with no CHD by ELISA.It was measured in 86 patients with positive coronary angiography and 15 patients with negative coronary angiography and it was also measured in 54 patients complicating CHD and 13 patients complicating no CHD of diabetes/ impaired glucose metabolism.Result：The concentrations of serum adiponectin was 3.9985±0.2147mg/L in patients with CHD,it was 3.9192±0.2182mg/L in patients with positive coronary angiography,and it was 3.9582±0.1868mg/L in patients with diabetes/ impaired glucose metabolism complicating CHD.They were decreased compared with controls respectively（P0.05）.Conclusion：Decrease of adiponetin might be relational new index in adjunctive diagnosis of CHD or estimation the serious degree of CHD.It also might be new forecast index in diabetes complicating CHD.It will be larvaceous applied value in clinic.
出处
《生物技术》
CAS
CSCD
北大核心
2010年第5期87-89,共3页
Biotechnology
基金
北京市教育委员会科技发展基金项目(KM200510025004)资助
关键词
脂联素
冠心病
糖尿病
冠状动脉造影
adiponectin
coronary heart diseases
diabetes
coronary angiography
