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过氧化物酶体增生物激活受体介导的前列环素/前列环素类似物相关药理作用研究进展

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摘要 自20世纪70年代发现前列环素（Prostacyclin,PGI2）以来,人们就开始探讨PGI2/PGI2类似物的作用及途径。此前有研究发现,PGI2/PGI2类似物可与其受体（Prostacyclin receptor,IP）结合,激活腺苷酸环化酶（AC）,升高环磷腺苷（cAMP）,进而激活cAMP依赖性蛋白激酶（PKA），发挥舒张血管、抑制血小板聚集、抑制血管平滑肌细胞增殖和迁移、促进血管平滑肌细胞分化等作用。
作者 房文通 李宏建 周聊生
机构地区 江苏省人民医院药剂科 山东大学附属千佛山医院药学部 山东大学附属千佛山医院老年医学部
出处 《中国药房》 CAS CSCD 北大核心 2010年第41期3922-3924,共3页 China Pharmacy
关键词 前列环素类 生物激活 受体介导 过氧化物酶体 抑制血管平滑肌细胞增殖 药理作用 cAMP依赖性蛋白激酶 receptor
分类号 R96 [医药卫生—药理学]
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参考文献15

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二级参考文献10

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中国药房
2010年 第41期

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