摘要
目的 研制一种血管内治疗颅内动脉瘤的液体栓塞剂—醋酸纤维素聚合物（ＣＡＰ） 。方法 寻找自制ＣＡＰ溶液的最佳配比； 在１２ 只家兔右侧股动脉内注入此溶液， 观察栓塞效果和组织病理变化。结果 表明ＣＡＰ溶液最佳配比为２５０ｍｇＣＡＰ、３ｍｌ ＤＭＳＯ和８００ｍｇＢｉ２Ｏ３ 。此溶液易于通过微导管， 不产生粘堵， 凝固约需５ 分钟； 并且具有组织相容性好、无毒副作用和栓塞血管腔完全牢固持久的优点。
Objective To research the cellulose acetate polymer (CAP) solution which was used as a new liquid thrombotic material for endovascular treatment of intracranial aneurysm.Methods In vitro, the best proportion of CAP solution was found.In vivo, the right femoral arteries of 12 rabbits were embolized with CAP solution mixed by ourselves.Results The best proportion of CAP solution is 250mg CAP, 3ml DMSO and 800mg Bi 2O 3 CAP solution which had a better absorption in X ray and didn't adhere to the microcatheter.The material solidified over a period of 5 minutes and remained a hard solidity.In vivo, CAP solution which was nontoxic and biocompatible embolized the lumen of the artery completely and permanently.Conclusion CAP solution is a relatively ideal embolic agent which need farther study.
出处
《中华神经外科杂志》
CSCD
北大核心
1999年第3期170-172,共3页
Chinese Journal of Neurosurgery
关键词
血管内
颅内动脉瘤
CAP
栓塞疗法
液体栓塞剂
Endovascular embolization Cellulose acetate polymer Intracranial aneurysm
