摘要
流通池法作为一种新型的溶出度检查方法,有着广阔的应用前景,特别是在药物释放支架、混悬剂、植入剂及微球、脂质体等新剂型中的应用更是具有很大的实用价值,可以很好地弥补传统溶出度方法的不足。在国外,流通池法正逐渐成为溶出度研究的热点。本文系统地介绍了流通池法的历史、现状及应用原理,并对其目前国内外的应用情况做了归纳、总结和前景预测,进一步探讨了流通池法在体内外相关性研究的优越性。
As an innovative dissolution test method,flow through cell method is suitable for a wide range of applications,especially for evaluation of brackets for drug release,suspensions,implanting preparations,microsphere and liposome.The new method offsets well the deficiency of traditional dissolution test way and has a great practical value.Flow through cell method is becoming a hot spot in dissolution tests abroad.In this paper,the development course,current status,applications of flow through cell method is described and summed up.We has also predicted development prospect of flow through cell method,and further revealed the superiority of flow-through cell method for evaluation of in-vitro and in-vivo correlations.
出处
《天津药学》
2010年第5期53-57,共5页
Tianjin Pharmacy
关键词
流通池法
释放
体内外相关性
flow through cell method
release
in vitro-in vivo correlation
