摘要
目的：评价超顺磁性氧化铁粒子（ＳＰＩＯ）增强ＭＲＩ区分肝腺瘤样增生与早期肝癌的可能性。材料与方法：建立二乙基亚硝胺诱发的大鼠肝癌模型；分析ＳＰＩＯ增强前后（６ｍｇＦｅ／ｋｇ）大鼠肝癌灶与肝腺瘤样增生结节的强化特征，并与病理检查进行对照。结果：８只大鼠肝癌模型共产生２５个癌结节和３２个肝腺瘤样增生结节，大小分别为６．２ｍｍ±３．０ｍｍ和４．１ｍｍ±３．６ｍｍ。在质子加权和Ｔ２加权像上，癌结节与肝腺瘤样增生结节多呈略高信号或等信号；增强后肝腺瘤样增生结节的信号强度有不同程度下降，但癌结节的信号强度相对不变。结论：观察ＳＰＩＯ增强前后信号强度的变化，对指导肝腺瘤样增生和肝癌结节的鉴别诊断有重要作用。
Objective: To evaluate the superparamagnetic iron oxide particles (SPIO) in differentiating early hepatocellular carcinoma (HCC) from adenomatous nodules (AH). Materials and Methods: Experimental model of HCC was established in 8 rats by oral administration of diethylnitrosamine (DENA). MR images were obtained before and 30 minutes after intravenous injection of SPIO (6 mgFe/kg) by using SE sequence (TR=2 000ms, TE=2090ms) in all 8 rats. MRI features of AH and HCC were analyzed and correlated with pathological findings. Results: At autopsy, 8 experimental rats totally demonstrated 25 HCC lesions and 32 AH nodules, with the average diameter of 6.2mm3.0mm and 4.1mm3.6mm, respectively. On PDWI and T2WI, most HCC and AH were visualized as hyper or isointensity areas. However, after injecting SPIO, the signal intensity of AH decreased to some degree, while HCC remained as same intensity as before. Conclusion: SPIOenhanced MRI is helpful in differentiating early HCC lesions from AH nodules.
出处
《临床放射学杂志》
CSCD
北大核心
1999年第6期371-373,共3页
Journal of Clinical Radiology
基金
6年国家新药基金
