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胰高血糖素样肽-1及相关降糖药物的研究进展 被引量：2

Advances in research on glucagon-like peptide-1 and its analogues
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摘要 胰高血糖素样肽-1(glucagon-like peptide-1,GLP-1)是近几年糖尿病治疗药物研究的热点之一,具备多重降血糖作用。它的两大类药物:GLP-1类似物和二肽基肽酶-Ⅳ抑制剂作为新的降糖药物相继完成临床研究,并在糖尿病治疗中发挥越来越重要的作用。本文就GLP-1的结构、药理作用以及两类相关降糖药物的临床应用作一概述。 Glucagon-like peptide-1（GLP-1） is one of the hot spots of research on antidiabetic agents in recent years.It has been proved that GLP-1 has multiple effects on antihyperglycemia.Clinical studies of GLP-1 analogues and dipeptidyl-peptidase Ⅳ inhibitor have been completed.As new types of antidiabetic agents,they are playing more and more important role in the treatment of type 2 diabetes.In this article,the structure and pharmacological function of GLP-1,research progress and clinical use of the GLP-1 analogues and dipeptidyl-peptidase Ⅳ inhibitor are reviewed.
作者 薛嵩 刘志民
机构地区 第二军医大学长征医院内分泌科
出处 《药学服务与研究》 CAS CSCD 2010年第5期321-324,共4页 Pharmaceutical Care and Research
关键词 胰高血糖素样肽-1 胰高血糖素样肽-1类似物 降血糖药 二肽基肽酶-Ⅳ 综述 glucagon-like peptide-1 glucagon-like peptide-1 analogues hypoglycemic agents dipeptidyl-peptidase Ⅳ review
分类号 R977.15 [医药卫生—药品]
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参考文献29

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二级参考文献28

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药学服务与研究
2010年 第5期

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