摘要
目的考察莪术对四氯化碳(CCl4)所致大鼠急性肝损伤的保护作用。方法将40只Wistar大鼠随机分为4组,即正常对照组,模型对照组,联苯双酯组及莪术给药组,分别灌胃等容积(15ml/kg)的生理盐水,联苯双酯(13mg/ml)和莪术溶液(6.3mg/ml),连续7d,1次/d。末次给药后,除正常组外其他各组腹腔注射CCl4(2ml/kg)原液1次,造成大鼠急性肝损伤模型,检测血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、考马斯亮蓝蛋白、丙二醛(MDA)及超氧化物歧化酶(SOD)水平。结果与模型组比较,莪术给药组ALT、AST及MDA含量均明显降低(P<0.01),SOD活性明显升高(P<0.01);莪术给药组与联苯双酯组比较,AST、ALT及MDA、SOD水平无显著差异(P>0.05)。结论中药莪术对CCl4所致大鼠急性肝损伤具有保护作用。
Objective To observe the effect of Rhizome curcuma on acute liver injury induced by CCl4 in rats. Methods 40 Wistar rats were randomly divided into four groups： the normal control group,the model control group,the Rhizome Curcuma group and the bifendate group. They were administered with NS,Rhizome Curcuma （ 6. 3 mg/ml） and bifendate （ 13 mg/ml） at the equal volume（ 15 ml/kg） once daily for seven days. After the last administration,all groups except the normal group were injected with CCl4（ 2 ml/kg） stock solution to induce acute hepatic injury model. Five biochemical indexes were detected,including ALT, AST,PROTEIN,MDA and SOD. Results Compared with the model group,the contents of ALT,AST,PROTEIN and MDA were remarkably decreased （ P 0. 01） ,the activity of SOD was remarkably improved （ P 0. 01） . The contents of AST,ALT and MDA,SOD in the Rhizome Curcuma group were similar to those in bifendate group （ P 0. 05） . Conclusion Rhizome Curcuma has protective effects on acute hepatic injury of rats induced by CCl4.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2010年第10期2460-2461,共2页
Lishizhen Medicine and Materia Medica Research
基金
黑龙江省自然科学基金(No.D200918)
关键词
莪术
肝损伤
四氯化碳
Rhizome Curcuma
Hepatic injury
CCl4
