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急性冠状动脉综合征介入治疗围手术期IL-6、IL-8及CRP的变化 被引量：3

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摘要 目的观察急性冠状动脉综合征(ACS)患者介入治疗围术期白细胞介素6(IL-6)、白细胞介素8(IL-8)及高敏C反应蛋白(hs-CRP)的变化情况及与疾病的相关性。方法收集122例患者介入治疗术前、术后血液样本,采用ELISA检测患者血清中的IL-6和IL-8表达水平,免疫散射比浊法检测样本中hs-CRP表达水平,并运用描述性统计、秩和检验、相关性分析等方法进行统计学分析。结果介入治疗患者手术前后IL-8和hs-CRP水平差异有显著性(P<0.05)。术前hs-CRP水平在急性心肌梗死(AMI)患者水平均较不稳定型心绞痛(UAP)患者水平高(P<0.05),且冠状动脉双支病变患者较单支病变的患者高(P<0.05)。术后3个指标在AMI及UAP患者间均无统计学意义(P<0.05)。结论 hs-CRP可能是导致ACS的危险因素,可能与ACS的发生发展有关。hs-CRP和IL-8可用于ACS介入治疗围手术期患者的病情观察。
作者 吕渭辉 陈纪言 阮新民 任毅
机构地区 广州中医药大学DME中心 广东省人民医院广东省医学科学院广东省心血管病研究所心内科 广东省中医院心脏中心
出处 《广东医学》 CAS CSCD 北大核心 2010年第15期1969-1970,共2页 Guangdong Medical Journal
基金 国家十一五科技支撑重大项目资助(编号:2006BAI04A01)
关键词 急性冠脉综合征 介入治疗 围手术期 白介素6 白介素8 C-反应蛋白
分类号 R543.3 [医药卫生—心血管疾病]
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参考文献11

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共引文献14

同被引文献28

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二级引证文献15

广东医学
2010年 第15期

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