摘要
目的分析慢性乙型重型肝炎抗病毒后影响预后的因素,探讨慢性乙型重型肝炎治疗策略。方法通过回顾性观察153例慢性乙型重型肝炎的临床资料,包括年龄、性别、白蛋白(ALB)、总胆红素(TB)、凝血酶原时间(PT)、甲胎蛋白(AFP)、胆碱酯酶(CHE)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、乙肝病毒核酸(HBV DNA)载量、是否存在肝硬化和是否存在并发症等情况,采用Cox比例风险模型对可能影响其预后的因素进行单因素和多因素回归分析。结果其中年龄、TB、PT、是否存在肝硬化、是否存在并发症是影响预后的独立因素。结论年龄、TB、PT、是否存在肝硬化、是否存在并发症对患者的预后有相关。
Objective To investigate the prognostic factors of severe chronic hepatitis B after anti-viral therapy and explore the therapeutic strategies of the treatment of hepatitis B.Method 153 patients with hepatitis B were retrospectively reviewed.Data of age,gender,ALB,TB,PT,AFP,CHE,ALT,AST,HBV DNA load,the existence of baseline cirrhosis and the existence of complications were collected.Univariate and multivariate analyses were performed by using cox proportional hazard model to screen prognostic factors.Result Independent risk factors of hepatitis B included age,TB,PT,the existence of cirrhosis and complications.Conclusion Include age,TB,PT,the existence of cirrhosis and complications associate with the prognosis of patients with hepatitis B.
出处
《中国微生态学杂志》
CAS
CSCD
2010年第10期925-927,共3页
Chinese Journal of Microecology
关键词
慢性乙型重型肝炎
抗病毒治疗
预后
Severe chronic hepatitis B； Anti-viral therapy； Prognostic；
