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甲胎蛋白异质体检测在肝癌诊断中的意义 被引量:5

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摘要 目的 探讨甲胎蛋白异质体检测在诊断肝癌中的临床应用价值.方法 选择临床检测甲胎蛋白阳性(≥20μg/L)的78例肝癌和72例非肝癌患者.使用亲和离心管方法检测甲胎蛋白异质体,比较它和甲胎蛋白在鉴别肝癌的作用.结果 以甲胎蛋白异质体≥10%作为诊断指标,肝癌患者血清中甲胎蛋白异质体异常升高者明显高于其他肝病患者(P<0.001);对78例临床确诊为肝癌的患者甲胎蛋白异质体的诊断灵敏度是71.79%(56/78);在72例临床诊断为其他肝脏疾病的患者甲胎蛋白异质体的诊断特异性达到91.67%(66/72);甲胎蛋白异质体的符合率81.33%[(56+66)/150].结论 应用新型亲和离心柱法检测甲胎蛋白异质体AFP-L3在肝癌与良性肝脏病变鉴别诊断中具有重要临床价值.
出处 《中国基层医药》 CAS 2010年第20期2799-2800,共2页 Chinese Journal of Primary Medicine and Pharmacy
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