摘要
目的：研制中药醒鼻温敏凝胶并考察其体外释药行为。方法：以泊洛沙姆407为凝胶材料,以泊洛沙姆188,PEG6000调节胶凝温度,并采用正交试验筛选处方,采用数学模型拟合体外释放曲线。结果：醒鼻温敏凝胶在3233℃胶凝,释药行为符合Higuchi方程。结论：醒鼻温敏凝胶处方设计合理,可进一步研究开发。
Objective： To prepare the nasal thermosensible gels of Chinese medicine Xingbi and study the release mechanism.Method： The gels were prepared by using P407 as the gel matrix and P188 and PEG 6000 were used to adjust the gelatination temperature.The formulations were screened by the method of orthogonal test.Mathematic models were used to imitate the drug release.Result： 20% poloxmar 407,2% poloxmar 188 and 2% PEG 6000 were suitable to Chinese medicine Xingbi thermosensitive gel in situ.Nasal thermosensible gels of Chinese medicine Xingbi was gelated at the temperature between 32-34 ℃ and the dissolution curves in vitro showed that the drug release could be best described by the Higuchi equation.Conclusion： The formulation of the nasal thermosensible gels of Chinese medicine Xingbi is reasonable and it is worth doing further research.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2010年第21期2822-2825,共4页
China Journal of Chinese Materia Medica
基金
国家高技术研究发展专项(2007AA021810)
关键词
醒鼻温敏凝胶
鼻黏膜给药
体外释放度
Chinese medicine Xingbi
nasal drug delivery
release rate in vitro
