摘要
目的:研究丹红注射液对大鼠缺血再灌注损伤的保护作用。方法:采用线栓法建立大鼠脑缺血再灌注模型,观察丹红注射液对脑缺血再灌注损伤大鼠的神经功能评分、脑组织中一氧化氮合酶(NOS)、一氧化氮(NO)、超氧化物歧化酶(SOD)、丙二醛(MDA)等的影响。结果:丹红注射液可显著降低脑缺血再灌注大鼠的神经功能评分,减轻脑组织损伤程度;提高SOD活力,降低MDA和NO、NOS水平。结论:丹红注射液对大鼠缺血再灌注损伤具有明显的保护作用。
Objective：To investigate the protection of Danhong Injection on the cerebral ischemia-reperfusion injury of rats.Methods：The models of focal brain ischemia-reperfusion injury were prepared by middle cerebral artery occlusion （MCAO） in rats.The effects of Danhong Injection on the cerebral ischemia-reperfusion injury of rats, such as nerve function grade and contents of NOS, NO, SOD, and MDA in brain tissues, were observed.Results：Danhong Injection could decrease the nerve function grade, improve the vigor of SOD, depress the levels of MDA, NO, and NOS.Conclusion：Danhong Injection can protect the brain from ischemia-reperfusion injury in rats.
出处
《药物评价研究》
CAS
2010年第5期388-390,共3页
Drug Evaluation Research
关键词
丹红注射液
脑缺血再灌注损伤
大鼠
神经功能
Danhong Injection
cerebral ischemia-reperfusion injury
rat
nerve function
