摘要
观察超氧化物歧化酶(SOD)对大鼠根尖周炎的作用效应并探讨其可能的作用机制。将48只诱导性根尖周炎大鼠随机分为3组,根管机械预备后即刻分别充填SOD和氢氧化钙(CH)以及空白封闭,分别于术后1、2、3、5周各处死4只;所有动物处死后拍摄根尖周X线片并制作组织学切片。实验数据采用SPSS12.0软件包进行单因素方差分析和配对t检验。SOD组和CH组在根管充填术后1周根尖周都有轻度炎性细胞浸润,2周时根尖周炎症好转,3周后已无明显炎症细胞存在。3周和5周时,SOD/CH组根尖周间隙与正常组之间差异无显著性(P>0.05),与对照组比较阴影面积有显著差异(P<0.01)。实验结果表明,SOD能消除根尖周炎症和促进根尖周硬组织修复,是生物相容性较好的根管治疗药物。
The purpose of this investigation was to elucidate the effects of superoxide dismutase（SOD） on the induced periapical periodontitis in rat,and to shed light on the possible mechanism involved in root canal therapy.48 Wistar rats with induced periapical periodontitis were randomly divided into 3 groups;their root canals of molar teeth were prepared;and the root canals were filled with SOD,CH,and nothing,respectively.At 1,2,3 and 5 weeks after operation,4 animals were killed respectively.Periapical roentgenogram and periapical pathological slices were made.The results were analyzed statistically by F test and t test with SPSS12.0 software package.After root canal therapy,mild inflammatory infiltration was observed in SOD and CH groups at 1 week.At 2 weeks,periapical periodontitis was improved.After 3 weeks,there was no inflammatory cell observed in SOD/CH group.At 3 and 5 weeks,no significant difference in periapical radiographic findings was noted between the experimental groups and normal group（P〉0.05）.The periapical radiographic lesion in control group was larger than that in SOD and CH groups（P〈0.01）.The results showed that SOD could control periapical inflammation and induce the proliferation of dentin and cementum.Therefore,SOD might be an ideal biocompatible material for root canal therapy.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2010年第5期1066-1069,共4页
Journal of Biomedical Engineering
基金
山东省卫生科技发展计划基金资助项目(2001CA1CFB4)
关键词
超氧化物歧化酶
氢氧化钙
根尖周炎
根管治疗
效应
大鼠
Superoxide dismutase（SOD）； Calcium hydroxide（CH）； Periapical periodontitis； Root canal therapy； Effect； Rat；
