摘要
探讨糖尿病（ＤＭ）大鼠心肌胰岛素含量变化与Ｓｅ和维生素Ｅ（ＶＥ）之间的关系。方法：应用低Ｓｅ复加注射链脲佐菌素（ＳＴＺ）制造ＤＭ模型，结合放免分析技术检测血清与心肌胰岛素含量。结果：低Ｓｅ、低ＶＥＤＭ大鼠心肌胰岛素含量明显减少，单纯补Ｓｅ或ＶＥ对心肌胰岛素含量的影响无统计学意义，而联合补Ｓｅ和ＶＥ则显著提高了ＤＭ大鼠心肌胰岛素水平。结论：ＤＭ时，Ｓｅ和ＶＥ所产生的联合生物学效应可以明显改善心肌细胞对胰岛素的摄取和利用，对改善ＤＭ时心肌细胞代谢与机能，防止ＤＭ心肌病变的发生发展可能起一定作用。
Abstract Objective: The relationship between Se， VE and insulin contents in myocardium was investigated in Sedeficient DM rats． Methods: On the basis of Sedeficient rat model， the injection of STZ was used to induce DM model． The insulin level in myocardium， serum， and pancreas was measured by RIA method． Results: Both Se and VE deficiency led to the decrease of insulin content in myocardium． The diets supplemented with either Se or VE failed to increase the insulin contents． However， supplementation of both Se and VE significantly increased the insulin level in myocardium． Conclusion:It suggests that combined Se and VE may increase the insulin intake and utilization in myocardic cells in DM rats， and it may play an important role in protecting myocardium from DM myocardial lesions． Key words: diabetes myocardium insulin selenium Vitamin E
出处
《营养学报》
CAS
CSCD
北大核心
1999年第2期177-180,共4页
Acta Nutrimenta Sinica
基金
国家自然科学基金
