摘要
体内氧浓度的稳定是机体维持自身功能的一个必要条件。在低氧条件下,机体内部在低氧信号的刺激下形成一个强大的防御体系以保护自己的组织。在采取防御的过程中,低氧诱导因子-1(hypoxia inducible factor-1,HIF-1)、血管内皮生长因子(vascular endothelial growth factor,VEGF)、促红细胞生成素(erythropoietin,EPO)、核因子-κB(nuclear factor-κB,NF-κB)等基因表达上调。HIF-1是一个与低氧胁迫相关的转录因子,它的激活与体内氧浓度相关。VEGF是HIF-1下游的一个靶基因,它是至今发现的一个在促血管新生方面起着最关键作用的因子。NF-κB能够抑制由低氧引起的细胞凋亡。以上这些基因在动物抗低氧胁迫方面起着重要作用,综述了低氧条件下HIF-1、VEGF、EPO、NF-κB的功能、表达特性以及调控机制。
Maintenance of oxygen homeostasis is important to cellular and systemic function.Under hypoxia condition,a powerful defense of organism is triggered by the hypoxia signal to protect tissue and organs.In the process of defense,some genes are up-regulated,such as hypoxia inducible factor-1（HIF-1）、vascular endothelial growth factor（VEGF）、erythropoietin（EPO）and nuclear factor-κB（NF-κB）.HIF-1 is a anti-hypoxia stress-related genes and encodes a transcription factor,The regulation of HIF-1 activity is related to the oxygen concentration.VEGF is a target gene of HIF-1,which is one of the most critical antigenic factor identified to date.EPO can promote the differentiation and proliferation of red blood cells under hypoxia conditions.NF-κB can inhibit cell apoptosis which is induced by hypoxia.Obviously,these genes play important roles in protecting organism from hypoxia stress.The function,expression pattern and regulation mechanism of HIF-1,VEGF,NF-κB and EPO in hypoxia are summarized.
出处
《中国生物工程杂志》
CAS
CSCD
北大核心
2010年第10期79-85,共7页
China Biotechnology
