摘要
目的探讨丙泊酚对不同抗高血压治疗后自发性高血压大鼠(SHR)血流动力学和血浆、心肌及主动脉中血管紧张素Ⅱ浓度的影响。方法 32只SHR随机分为四个抗高血压治疗组:卡托普利组(A组)、普萘洛尔组(B组)、双氢克尿塞组(C组)和非洛地平组(D组),每组8只。在抗高血压治疗12周后,大鼠以丙泊酚5mg/kg诱导,继之以丙泊酚60mg·kg-1.h-1持续输注30min,观察输注期间MAP和HR变化,并于结束时处死大鼠,测定血浆、心肌及主动脉中血管紧张素Ⅱ浓度。结果各组MAP、HR随着丙泊酚输注进行性下降和减慢,其中血流动力学抑制在A组最为明显,且A组各部位的血管紧张素Ⅱ浓度显著低于其它组(P<0.05)。结论丙泊酚麻醉对不同抗高血压治疗后高血压大鼠血流动力学有抑制作用,卡托普利治疗后抑制最明显;丙泊酚对血流动力学抑制与体内血管紧张素Ⅱ浓度降低可能有关。
Objective To evaluate the effects of propofol on the hemodymamics as well as the levels of angiotensin Ⅱ from plasma, myocardium and aorta in spontaneously hypertensive rats （SHR） after various antihypertensive therapies. Methods Thirty two SHR were randomly divided into four anti-hypertensive treatment groups： captopril （ group A ）, propranolol （ group B ）, dihydroehlorothiazide （group C） and felodipine （group D） （n=8 per group）. After twelve weeks of antihypertensive treatment, SHR were first induced with a bolus of 5mg/kg propofol followed by an infusion of 60 mg·kg^-1·h^-1 propofol for 30 min. MAP and HR were monitored continuously during infusion. The levels of Angiotensin Ⅱ from plasma, myocardium and aorta were measured at the end of the infusion. Results MAP and HR decreased during the propofol infusion in all groups. The inhibition of hemodynamics in group A was significant than those in other groups. Angiotensin Ⅱ in plasma, the myocardium and aorta was significantly lower in group A than that in group B, C and D. Conclusion Propofol inhibits hemodynamics in SHR with various antihypertensive therapies, especially those treated with captopril, which could be related to the decrease of body angiotensin Ⅱ.
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
2010年第10期889-891,共3页
Journal of Clinical Anesthesiology
基金
福建省自然基金资助项目(2009J01159)
