摘要
目的:探讨癌胚抗原(CEA)、糖链抗原125(CA125)、神经元特异性烯醇化酶(NSE)、细胞角蛋白19片段(CYFRA21-1)四项指标联合检测在肺癌诊断中的价值。方法:应用电化学发光技术和放射免疫法检测60例正常对照,60例肺癌和60例肺良性疾病血清中的CEA、CA125、NSE、CYFRA21-1的含量。结果:肺癌组四项指标均明显高于肺良性疾病组和健康对照组,差异具有统计学意义(P<0.01)。四项指标联合检测可显著提高肺癌诊断的敏感性和特异性。结论:四项指标对肺癌诊断具有一定的价值,且联合检测具有较高的临床实用价值。
Objective： To study the diagnostic significance of four serum tumor markers（CEA,CA125,NSE,and CYFRA21-1） measured together for lung cancer.Methods： The four serum level of CEA,CA125,NSE and CYFRA21-1 was tested by the electro-chemiluminescence technic and the radioimmunoassay（RIA） among 60 patients with lung cancer and compared to 60 patients with benign lung diseases and 60 healthy people.Results： The level of the four serum tumor markers in the 60 patients with lung cancer was markedly higher than that in the 60 patients with benign lung diseases and 60 healthy people,and the differences had statistical significance（P〈0.01）.The four serum level measured together could evidently enhance sensitivity and specificity of lung cancer diagnose.Conclusion： The four serum level of CEA,CA125,NSE and CYFRA21-1 is significant to the diagnosis of lung cancer and the four level measured together has the clinical practical value.
出处
《中国医药导报》
CAS
2010年第31期27-28,共2页
China Medical Herald
