摘要
目的评价吉西他滨固定剂量率输注联合化疗的安全性。方法入组4例常规化疗效果差的患者,应用吉西他滨以10mg/(m2·min)的固定剂量率输注,d1,8,21d为1个周期。同时联用其他化疗药物。其中1例接受6个周期的化疗,其余3例接受1～2个周期化疗。治疗后评价毒副反应。结果 4例均出现可逆性的骨髓抑制、胃肠道反应、一过性肝损害,但未见明显心肾毒性。结论吉西他滨固定剂量率输注联合化疗的毒副反应可耐受。
Objective To observe the safety of fixed dose rate infusion of gemcitabine in combination with chemotherapy.Methods Four patients with carcinoma were treated by fixed dose rate infusion of gemcitabine 10 mg/（m2·min）,d1,8 and in combined with other chemotherapeutics,repeated every 21 days.The toxicities were evaluated.Results The main toxicities were reversible myelosuppression,gastrointestinal reaction,transient hepatic lesion.Cardiac or renal toxicity was not detected.Conclusion The toxicities of fixed dose rate infusion of gemcitabine in combination with chemotherapy can be tolerated.
出处
《肿瘤基础与临床》
2010年第4期303-304,共2页
journal of basic and clinical oncology
基金
江苏省卫生厅康莱特临床研究基金(编号:P200908)
