摘要
目的研究硒对氟中毒大鼠体内氟、抗氧化酶和脂类代谢的影响作用。方法Ｗｉｓｔａｒ大鼠饮２．６３ｍｍｏｌ／Ｌ高氟水１０个月后分为氟、氟加２．０ｍｇ／ｋｇ硒、改饮正常水、改正常水加硒４组，再喂养１０个月。观察尿氟动态变化，测定骨、组织、血清氟和硒，同时测血ＧＳＨ－ｐｘ、ＳＯＤ、ＬＰＯ及血ＴＣ、ＴＧ、ＨＤＬ－Ｃ、ＬＤＬ－Ｃ等。结果氟加硒组较氟中毒组尿氟排泄增高，骨、组织氟降低，酶和脂代谢改善；改正常水加硒组，排尿氟和降体氟作用优于单纯改水组，酶和脂类指标水平更趋正常。结论一定浓度范围内的硒对氟中毒大鼠具有排高氟和调整自由基、脂类代谢紊乱作用。改正常水加硒则有促进氟中毒恢复的作用。
Objective Study on effects of selenium(Se) on fluorine (F),anti oxidation enzymes and lipid metabolism in rats with fluorosis.Methods Wistar rats with chronic fluorosis which were duplicated with 2.63mmol/L F in drinking water for 10 months divied into 4 groups(1)high F water (2.63mmol/L);(2)high F water and Se supplementation (2.0mg/kg) in fodder;(3)normal water;(4)normal water and Se for 10 months.The contents of F in urine were observed tendentiously,F in bones,liver,kidneys and serum were tested.The activities of glutathione peroxidase (GSH px) and superoxide dismutase (SOD) in erythrocyte,liver and kidneys,the contents of total cholesterol (TC),high density lipoproteincholesterol (HDL C) and low density lipoproteincholesterol (LDL C) in serum were determinde.Results There was an increase of urine F and a decrease of liver,kidneys and bones F,anti oxidation enzymes and lipid metablism improved in high F and Se group compared with high F group.The function of promoting excretion of F and decreasing tissue and bones F in normal water and Se group had the advantage of that in normal water group,at the same time,the level of anti oxidation enzymes and lipid approached it in control group.Conclusions Se in the range of certain concentration had the role of excreting high F,adjusting disorder of free radicals and lipid metablism,and promting the recovery of fluorosis in rats with fluorosis.
出处
《中国地方病学杂志》
CAS
CSCD
1999年第2期93-96,共4页
Chinese Jouranl of Endemiology
基金
山东省卫生厅资助
关键词
氟中毒
抗氧化酶
脂类
硒
大鼠
Fluorosis Anti oxidation enzymes Lipid Se
