摘要
ＢＡＬＢ／Ｃ小鼠随机分成２组，实验组和对照组。实验组小鼠隔日Ｔ２毒素灌胃，持续６周后，观察毒素在体内诱导骨髓嗜多染红细胞（ＰＣＥ）出现微核的情况。实验结果表明，给予１０ｍｇ／ｋｇ体重的Ｔ２毒素可诱导小鼠骨髓微核试验阳性，并且实验组微核率明显高于对照组，差异有显著性（Ｐ＜００５），提示Ｔ２毒素可引起小鼠染色体畸变，具有致畸潜力。
The experimental mice were randomly divided into 2 groups:Control group and T2 toxin group.Mice in group 2 were fed to T2 toxin in 6 consecutive weeks and the micronucleus of polychromatic erythrocytes(PCE) induced by T2 toxin was observed.The experimental results showed that 1.0mg/kg T2 toxin could lead to positive result of mice bonemellow micronucleus experiment.The micronucleus rate in group 2 was much higher than that in control group.The difference between the two groups was significant.The above mentioned results suggest that T2 toxin can bring about chromosome aberration in mice and possesses potential teratogenicity.
出处
《哈尔滨医科大学学报》
CAS
1999年第2期91-92,共2页
Journal of Harbin Medical University
