摘要
目的分析引起老年患者肺部感染的病原菌分布特点及耐药特征,为临床合理使用抗菌药物提供依据。方法对医院2007年1月-2008年12月522例老年患者痰标本分离出的177份阳性标本进行病原学及药敏分析。结果 177份阳性标本中共分离出182株病原菌,有6例为混合感染;感染率最高的病原菌前5位依次为:白色假丝酵母菌(43.41%)、肺炎克雷伯菌(13.19%)、大肠埃希菌(8.79%)、鲍氏不动杆菌(5.49%)、鲁氏不动杆菌(4.39%);常见的革兰阴性杆菌对常用的抗菌药物存在不同程度的耐药,革兰阳性球菌高度耐药,只有利福平和万古霉素敏感率较高。结论引起老年患者肺部感染的病原菌分布及药敏情况有其相应特点,相关分析对指导临床合理使用抗菌药物具有重要意义。
OBJECTIVE To analyze the distribution and drug resistance of pathogenic bacteria isolated from aged patients with pulmonary infection, and provide the guidance for the reasonable use of antibiotics in clinical therapy. METHODS Retrospectively analyzed on etiology and drug sensitivity for 177 positive sputum samples isolated from 522 aged patients between Jan 2007 and Dec 2008. RESULTS Totally 182 strains of pathogenic bacteria were isolated from 177 positive samples , and 6 cases were with mixed infection. The top five pathogens with the highest infeetive rate were：Candida albicans （43.41%）, Klebsiella pneumoniae （13. 19%）, Esherichia coli （8.79%）, Acinetobacter baurnannii/haemolyticus （5.49%）, and Acinetobacter lzeoffii （4. 39 %）. Common Gram-negative bacteria were resistant to the common antibiotics in different degrees. Gram-positive bacteria were highly dug- resistant, and only rifampicin and vancomycin had higher sensitive rates. CONCLUSIONS The pathogenic bacteria distribution in aged patients with pulmonary infection and the drug sensitivity have their corresponding charactersistics, the correlated analysis is significant to guide the rational administration of drugs.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2010年第22期3590-3592,共3页
Chinese Journal of Nosocomiology
关键词
老年患者
肺部感染
病原菌
药敏分析
Aged patients
Pulmonary infection
Pathogens
Drug sensitivity analysis
