摘要
研究了８名健康志愿者口服单剂国产司帕沙星４００ｍｇ后的药物动力学特征。用高效液相色谱法（ＨＰＬＣ）测定血清和尿中药物浓度。该药在体内转运过程以二室模型拟合为佳。峰浓度（Ｃｍａｘ为１４９±０．２８ｍｇ／Ｌ，达峰时间（Ｔｍａｘ）为７．１２±１．１７ｈ，消除半衰期（Ｔ１／２β）为２２±６．８３ｈ，系统清除率（Ｃｌｍ）为８．８５±２．１６Ｌ／ｈ，表观分布容积（Ｖｄ）为２．７３Ｌ／ｋｇ，血药－时曲线下面积（ＡＵＣ）为４７．３５±１０．２４（ｍｇｈ）／Ｌ，滞后时间（Ｔｌａｇ）为０．８９±０．８８ｈ。服药后２４、９６ｈ尿药排泄率仅为９．１６％和１５．６８％。
Sparfloxacin is a long acting, broad spectrum new quinolone antibacterial agent. Eight healthy male volunteers received 400mg of sparfloxacin in tablet form orally. Drug concentrations were determined by a high pressure liquid chromatography (HPLC) method. The two compatrment model was used. The mean peak serum level was 1.49±0.28mg/L. The mean peak time was 7.12±1.17h, pharmacokinetic parameters of sperfoxacin in healthy volunteers, plasma half life of elimination ( T 1/2β , serum clearance ( CL s), volume of appearance distribation ( V d) and area under curve (AUC) were 22±6.83h, 8.85±2.16L/h, 2.73L/kg, 47.35±10.24(mg·h)/L, respectively. Within 24 and 96h, the cumulative urinary recovery of unchanged drug amounted to 9.16% and 15.68% of the given dose respectively.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
1999年第2期152-155,共4页
Chinese Journal of Antibiotics
