摘要
目的探讨急性胰腺炎病程早期急性时相性蛋白变化规律及其临床意义。方法分别于入院第一、四、七和十四天对起病４天以内入院的２３例急性胰腺炎患者外周血中Ｃ反应蛋白等６种血清急性时相性蛋白进行检测。结果本组入院第一天急性胰腺炎患者Ｃ反应蛋白、α１酸性糖蛋白、铜蓝蛋白和触珠蛋白显著高于正常对照组（Ｐ＜００５），白蛋白显著低于正常对照组（Ｐ＜００５）；重症组Ｃ反应蛋白显著高于轻症组（Ｐ＜００１），转铁蛋白则显著低于轻症组（Ｐ＜００５）。第七天时重症组中有并发症者Ｃ反应蛋白显著高于无并发症者（Ｐ＜００５）。重症组中死亡者前白蛋白呈进行性下降，第十四天时显著低于存活者（Ｐ＜００５）。结论Ｃ反应蛋白和转铁蛋白可作为判断病情轻重的早期指标，Ｃ反应蛋白还能提示并发症的发生，前白蛋白对预后的估价有很大帮助。
Objective To investigate changes of six acute phase proteins and its clinical implications in patients with acute pancreatitis (AP).Methods Twenty three patients who were admitted within four days of onset were recruited. Serum concentration of C reactive protein (CRP),α 1 acid glycoprotein (AAG),Cerulopasmin (CER), Haptoglobin (HPT), Transferrin (TRF) and Proalbumin (PAB) were detected in days 1, 4, 7 and 14 after admission. Results Compared with the normal control group, the serum concentration of CRP, AAG, CER and HPT increased whereas PAB decreased markedly in AP group on the first day of admission ( P <0 05).The concentration of CRP was even higher in severe cases than that in mild cases ( P <0 01),whereas TRF was significantly decreased when compared with controls ( P <0 05). The concentration of CRP in severe patients with complication was significantly higher than that in those without complications on day 7 ( P <0 05). In severe group, PAB in patients who eventually died decreased continuously, and was significantly lower than that in survivors ( P <0 05). Conclusions At early stage the concentration of CRP and TRF could be used to predict the severity of the disease,sustained high level of CRP predicts complication, and PAB had a good prognostic value.
出处
《中华普通外科杂志》
CSCD
1999年第2期100-102,共3页
Chinese Journal of General Surgery
