摘要
采用开放试验与随机、双盲、双模拟平行对照方法观察国产卡维地洛（Ｃｖ）对原发性高血压病人的疗效，并与国产阿替洛尔（Ａｔ）作对比。Ｃｖ开放试验组３０例中显效２０例（６６７％），有效６例（２００％），总有效率２６例（８６７％）；随机双盲双模拟组中Ａ组（Ｃｖ组）２５例中总有效２１例（８４０％），Ｂ组（Ａｔ）２５例中总有效１８例（７２０％）。治疗４周前后血压下降幅值各组差异均有显著性（Ｐ＜０．０１）。不良反应少而轻。提示国产Ｃｖ系一安全有效的抗高血压病药物。
To compare the efficacy of native carvedilol(Cv) with native atenolol(At), we treated 80 cases of essential hypertension(stage Ⅰ Ⅱ) for 4 weeks, using both open test and double blind randomized imitative methods. The daily dose of carvedilol was 10mg to 40mg, and that of atenolol was 50mg to 100mg. Both drugs were given once daily. Out of 30 cases of Cv group, carvedilol showed significant efficiency in 20 cases, and was effective in 6 cases. The total therapeutic efficiency was 86.2%(26/30). In the double blind groups(25 patients in each group), those treated with carvedilol(Group A) had 21 effective cases(84.0%) while those treated with atenolol(Group B) had 18 effective cases(72.0%). A lower incidence of adverse effects was observed in carvedilol group. Dizziness occurred similarly in both drugs, but it lasted only a short time and could be tolerated. The recommended dose of 10～30mg once daily would be appropriate. After treatment there was a significant reduction in blood pressure in both groups( P <0.01). It suggests that native carvedilol is a safe and effective anti hypertensive agent.
出处
《湖南医科大学学报》
CSCD
1999年第2期153-156,共4页
Bulletin of Hunan Medical University
关键词
高血压
卡维地洛
药物疗法
carvedilol
hypertension
treatment
therapeutic use
