摘要
目的：了解肺癌细胞核ＤＮＡ倍性分布与肺癌临床病理类型（特征）的关系，研究测定癌旁细胞核ＤＮＡ倍性在判断肿瘤局部转移中的作用。方法：应用流式细胞仪（ＦＣＭ）测定手术切除的４８例新鲜肺癌组织标本，包括１６例癌旁肺组织细胞核ＤＮＡ倍体模式。结果：二倍体肿瘤主要分布于ＴＮＭ分期Ⅰ～Ⅱ期及分化好的Ⅰ～Ⅱ级肿瘤；随着肿瘤的病理分期或分级的发展，异倍体肿瘤的检出率逐渐上升，约７５％患者的肿瘤表现为异倍体ＤＮＡ类型。伴癌栓形成或淋巴结转移，Ⅲ～Ⅳ期肺癌其癌旁肺细胞核异倍体率有较明显升高。结论：测定癌及癌旁细胞核ＤＮＡ倍体模式，在评估肺癌恶性程度上有重要意义。
Objective: To study the relationship between the DNA ploidy and pathological characteris-tics in different types of lung cancer, as well as to find out if cellular ploidy in tissues adjacent to canceris relative to regional nodal metastasis. methods: Fresh surgical specimens of lung cancer from 48 pa-tients were examined by flow cytometry including 16 fresh specimens of lung tissue adjacent to cancer.Results:Diploidy mainly occurred in stage Ⅰ -Ⅱ and well - differentiated tumors. Aneuploidy increasedwith the escalation of pathological grade and poor differentiation of the tumor. In 75% of the patients aneu-ploidy was noted. The rate of aneuploidy of tissues adjacent to cancer was much higher when there wasthrombosis in tumor, lymphatic metastasis or when it was stage Ⅲ - Ⅳ lung cancer. Conclusion: Thestudy shows that investigating the ploidy of tumor and tissues adjacent to the tumor may be a predictor inevaluation of the tumor malignancy.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1999年第4期261-263,共3页
Chinese Journal of Clinical Oncology
