摘要
目的探讨低剂量施太可（１２０～１６０ｍｇ）对国人室性心律失常的疗效及安全性。方法选择１８０例２１～６５岁的室性早搏（室早）患者接受施太可治疗，施太可剂量从每天１２０ｍｇ开始，两周后达疗效标准者结束试验，未达标准者剂量加至１６０ｍｇ继续治疗两周，疗效及不良反应采用临床及动态心电图结果评定。结果（１）施太可每日１２０ｍｇ的有效率为５０．０％（ｎ＝９０），无效者剂量增至每天１６０ｍｇ的有效率仍可达３１．１％（ｎ＝２３），施太可两种剂量治疗的总有效率为６２．８％（ｎ＝１１３）。（２）既往经其它两种以上抗心律失常药物治疗失败的病例９６例，经施太可治疗后有效率可达５５．２％。（３）服施太可后第一周血压、心率显著下降，ＱＴｃ明显延长，Ｐ均＜０．０１，但继续服药后无进一步显著变化。（４）平均心率降低与室早减少存在显著相关性（ｒ＝０．２９，Ｐ＜０．００１）。（５）不良反应发生率为１２．２％，其中２例因心率＜５０ｂｐｍ，３例因血压＜９０／６０ｍｍＨｇ（１ｍｍＨｇ＝０．１３３ｋＰａ）于试验第一周内退出试验，１例出现服药后室早成倍增加，其余不良反应发生率较少而轻微。结论低剂量施太可（１２０～１６０ｍｇ·ｄ－１）对于国人的室早疗效确?
bjective To investigate the efficacy and safety of the low dose(120160 mgd-1)sotalol on ventricular arrhythmia of chinese patients. Method Totally 180 patients,age 2165 years old with ventricular premature complexes(PVCs)entered the study.The initial dose was 120 mgd-1.After two weeks,the dosage was titrated to 160 mgd-1 for those who had not reached the responsible criteria.Holter monitoring was used to assess the arrhythmias.The treatment duration was 24 weeks. Results (1)The effective rate of sotalol(120 mgd-1) with two week treatment was 50%(n=90).Patients with treatment failure received sotalol(160 mgd-1)for another two weeks,the effective rate was 311%(n=23).Therefore,the total effective rate was 628%(n=113).(2)For 96 patients who had treatment failure history by using more than two kinds of antiarrhythmia drugs,the effective rate reached 552%.(3)Blood pressure and heart rate decreased,while QTc interval increased significantly in the first week(P<001),but no further significant changes in the following weeks.(4)There was significant relationship between decreased PVCs and mean heart rate(MHR),r=029,P<0001,but no definite relationship between decreased PVCs and lengthened QTc interval.(5)The accident rate of adverse event was 122%,5 patients discontinued sotalol therapy due to serious sinus bradycardia(n=2)and hypotension(n=3). Conclusion Low dose sotalol was effective and safe in the treatment of Chinese patients with PVCs and proarrhythmic effect was rarely observed.
出处
《中华心律失常学杂志》
1999年第2期106-109,共4页
Chinese Journal of Cardiac Arrhythmias
