摘要
目的研究EZH2和Ki67蛋白在膀胱癌组织中的表达及其临床意义。方法采用免疫组化法对72例膀胱癌患者癌组织中的EZH2和Ki67蛋白进行测定。结果膀胱癌组织中EZH2及Ki67蛋白阳性率显著高于膀胱正常黏膜组织,差异有统计学意义(P<0.05)。结论 EZH2蛋白表达增高与膀胱癌的临床分期,复发密切相关,并与Ki67正相关。联合检测EZH2及Ki67可以作为反映膀胱癌预后的生物学因子。
Objective To study the clinical significance and expression of EZH2 and Ki67 in human bladder transitional cell carcinoma（BTCC）.Methods 72 cases of in BTCC were evaluated for EZH2 and Ki67 protein expression by immunohistochemical method.Results The positive expression level of EZH2 and Ki67 in BTCC which were higher than that in normal bladder transitional cell.The difference was significant（P0.05）.Conclusion Increased expression of EZH2 is correlated with cell clinical classification and recrudescence of BTCC,and positive correlated with the expression of Ki67.Detection of EZH2 and Ki67 can be used as a biological factor to reflect the prognosis of BTCC.
出处
《中国现代医药杂志》
2010年第11期72-74,共3页
Modern Medicine Journal of China
