摘要
在pH7.90的Britton-Robinson缓冲介质中,替米沙坦与偶氮胂Ⅰ染料反应,形成离子缔合物,溶液颜色发生明显改变,最大吸收波长在558nm,从而建立测定替米沙坦的分光光度法。在最大波长558nm处,替米沙坦浓度在0—2.25×10^(-5)mol/L时遵守比耳定律,表观摩尔吸光系数ε为3.14×10~4L/(mol·cm),检出限为5.93×10^(-7)mol/L。本法操作简便,体系稳定,灵敏度较高,选择性较好,用于临床用药和合成样中替米沙坦含量的测定,结果满意。
In Britton-Robinson of pH 7. 90 buffer medium,telmisartan reacts with arsenazo I to form an ion-association complex, the colours of solutions change obviously, the maximum absorbable wavelength is at 558nm, a sensitive spectrophotometric method is developed for determination of telmisartan. The concentration of telmisartan in the range of 0-2.25 × 10-5mol/I. obeys Beer＇s law at the maximum absorbable Wavelength,the apparent molar absorptivity is 3.14 × 10 4L/（mol · cm） , the detection limit is 5.93 × 10-7mol/L. The method has high sensitivity and fairly good selectivity, the method is applied to the determination of telmisartan in medicine sample and different mixture sample, with satisfactory results.
出处
《光谱实验室》
CAS
CSCD
北大核心
2010年第6期2191-2196,共6页
Chinese Journal of Spectroscopy Laboratory
基金
重庆市教委科学技术项目(No.KJ101314)
重庆市涪陵区科委科技计划(No:2008-43)
重庆市高等学校优秀中青年骨干教师资助计划[渝教人(2005)2号]
