摘要
目的 探讨食管-胃结合部腺癌肿瘤分化程度与相关病理学因素的关系.方法 对163例根治性手术切除的食管-胃结合部腺癌患者的病理资料进行分析,按照肿瘤分化程度分为分化好和分化差2组,比较2组间N分期、T分期、肿瘤大体类型、脉管癌栓等的病例构成情况以及2组间肿瘤大小和淋巴结转移个数的差异.结果 ①在分化好组,T分期、N分期低者所占比例大（T1和T2约占55.74%,N1和N2约占75.41%）,分化差组则以T分期、N分期高者为主（T3和T4约占59.81%,N2和N3约占57.85%）,2组间差异均有统计学意义（Z值分别为2.375、4.231,P＜0.05、P＜0.01）.②分化好组脉管癌栓发生率为44.26%（27/61）,低分化组为63.73%（65/102）,2组比较,差异有统计学意义（Z值为2.418,P＜0.05）.③2组间肿瘤大体形态类型的比例差异无统计学意义（Z值为0.613,P＞0.05）.④分化好组平均肿瘤大小和淋巴结转移个数分别为（4.27±2.00）cm,（4.15±5.27）枚;分化差组分别为（5.87±3.26）cm,（8.80±7.65）枚,2组比较差异均有统计学意义（t值分别为3.90、4.66,P均＜0.01）.结论 食管-胃结合部腺癌肿瘤分化程度对N分期、T分期、脉管癌栓形成、肿瘤大小及淋巴结转移等多种病理学因素具有显著影响.
Objective To investigate the relationship between the tumor differentiation and the related pathologic factors in Esophago-gastric junction adenocarcinoma. Methods The pathological data from 163 patients of Esophago-gastric junction adenocarcinoma underwent radical surgical resections were randomly divided two groups （group1： well-differentiated,group2： poor-differentiated）. The composition of N stages,T stages,morphological type and vessel carcinoma embolus were compared between the two groups ,respectively. The tumor sizes and the number of metastases lymph nodes were compared between the two groups. Results The cases with lower N stages or T stages in group1 were dominant（T1 and T2：55. 74%,N1 and N2：75.41%）. Oppositely,those with higher N stages or T stages were dominant（T3 and T4：59.81%,N1 and N2：57.85%）in group 2. The differences were significant Incidence of vessel carcinoma embolus was 44. 26%（27/61）in group 1 and 63. 73%（65/102）in group 2,with a significant difference. There was no significant difference for morphological type in the two groups. The tumor sizes and the number of metastases lymph was 4. 27 ±2. 00 cm and 4. 15 ±5.27 respectively in group 1 ,and 5. 87 ± 3. 26 cm and 8. 80 ± 7.65 respectively in group 2. The differences were significantly different（Ps 〈 0. 01）.Conclusions The tumor differentiation has significant effect on N stages,T stages,vessel carcinoma embolus,tumor size and the number of metastases lymph nodes in Esophago-gastric junction adenocarcinoma.
出处
《中国综合临床》
2010年第11期1189-1191,共3页
Clinical Medicine of China
关键词
消化道肿瘤
肿瘤分化
脉管癌栓
Tumor of digestive tract Differentiation Vessel carcinoma embolus
