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The Hepatoprotective Effects of Solanum Incanum on Acetaminophen-lnduced Hepatotoxicity in Guinea Pigs

The Hepatoprotective Effects of Solanum Incanum on Acetaminophen-lnduced Hepatotoxicity in Guinea Pigs
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摘要 Solanum incanum, a shrubby herb, is widely distributed and used as analgesic, antitoxic, and antispasmodic in folk medicine. In the present study, the protective effects of aqueous extract of S. incanum against acetaminophen induced acute liver damage were evaluated in guinea pigs. Animals were orally administered with S. incanum extract (50 and 100 mg/ kg bw) and silymarin ( 100 mg / kg bw) respectively for 6 days followed by acetaminophen administration (2 g / kg bw) at the 7th day. The results showed that the treatment with S. incanum extract significantly lowered the acetaminophen-induced serum levels of hepatic marker enzymes (AST, ALT, and ALP), Liver histopathology also showed that S. incanum extract reduced the incidence of liver lesions including the swelling of hepatic cells, lymphocytes infiltration, nucleus condensation, and hepatic necrosis induced by acetaminophen treatment in guinea pigs. The S. incanum extract at a dose of 100 mg / kg bw was more effective in suppressing the oxidative damage than the extract at a dose of 50 mg / kg bw. Therefore, the results of this study suggest that S. incanum extract could protect liver against the acetaminophen-induced oxidative damage.
出处 《Journal of Life Sciences》 2010年第5期44-48,共5页 生命科学(英文版)
关键词 Solanum incanum extract ACETAMINOPHEN HEPATOPROTECTION guinea pigs 对乙酰氨基酚 急性肝损伤 三氧化二砷 豚鼠 诱导 水提取物 保肝 作者
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