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宫颈病变中抗原呈递元件成员蛋白和人类白细胞共同抗原Ⅰ类分子表达的关系 被引量：4

Association of expression of antigen processing machinery components with HLA- Ⅰ in cervical lesions
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摘要 抗原呈递元件（APM）成员蛋白作为一组抗原呈递相关功能蛋白,在协助人类白细胞共同抗原（HLA）Ⅰ类分子组装、负载和提呈内源性抗原肽,介导抗病毒T细胞免疫中发挥着重要作用[1].其成员蛋白抗原处理相关转运体（TAP）负责将内源性抗原肽向内质网腔转运.TAP相关蛋白对HLA-Ⅰ类分子在内质网中的装配发挥关键作用[2].分子伴侣钙连接蛋白和钙网蛋白以及疏基二硫键氧化还原酶Erp57协助新合成的HLA-Ⅰ蛋白正确折叠和组装[3].人乳头状瘤病毒（HPV）是宫颈癌发生的始动因素,也可能通过协助肿瘤细胞影响HLA-Ⅰ基因表达调控.因此,探讨HPV感染引起宿主HLA-Ⅰ类分子表达缺失与APM成员表达情况有无关联,是揭示肿瘤的分子机制、疫苗治疗、建立肿瘤生物标志谱体系的关键.我们通过检测宫颈上皮内瘤变（CIN）和宫颈癌组织中APM成员蛋白及HLA-Ⅰ类分子的表达情况,分析其与HPV16感染的相关性,从而探讨宫颈病变中HLA-Ⅰ类分子表达下调的机制.
作者 阿仙姑·哈斯木 卿松 吴小川 葛璘 阿布力孜·阿布杜拉
机构地区 新疆医科大学病理学教研室 新疆医科大学生物化学与分子生物学教研室 新疆医科大学第一附属医院病理科 新疆维吾尔自治区人民医院妇科
出处 《中华病理学杂志》 CAS CSCD 北大核心 2010年第10期703-704,共2页 Chinese Journal of Pathology
基金 国家自然科学基金（81060164） 新疆维吾尔自治区自然科学青年基金（2009211B14）
关键词 宫颈病变 抗原呈递元件成员蛋白 人类白细胞共同抗原Ⅰ类分子 内质网
分类号 R686 [医药卫生—骨科学]
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参考文献7

  • 1Dunn GP,OldL J,Schreiber RD,et al.The immunobiology of cancer immunosurveillance and immunoediting.Immunity,2004,21(2):137-148.
  • 2Kienast A,Preuss M,Winkler M,et al.Redox regulation of peptide receptivity of major histocompatibility complex class Ⅰmolecules by ERp57 and tapasin.Nat Immunol,2007,8 (8):864-872.
  • 3Zhang Y,Williams DB.Assembly of MHC class Ⅰ molecules within the endoplasmic reticulum,Immunol Res,2006,34(1-2):151-162.
  • 4Chang CC,Ferrone S.Immune selective pressure and HLA class I antigen defects in malignant lesions.Cancer Immunol Immunother,2007,56(2):227-236.
  • 5马琦,阿仙姑·哈斯木,阿比达·阿不都卡德尔,夏米西努尔·伊力克,武贵臻,阿布力孜·阿布杜拉.维吾尔族妇女宫颈癌人乳头状瘤病毒感染与人类白细胞抗原Ⅰ类基因表达缺失的关系及其意义[J].中华病理学杂志,2010,39(4):255-258. 被引量：18
  • 6Mehta AM,Jordanova ES,Kenter GG,et al.Association of antigen processing machinery and HLA class Ⅰ defects with clinicopathological outcome in cervical carcinoma.Cancer Immunol Immunother,2008,57 (2):197-206.
  • 7Meissner M,Reichert TE,Kunkel M,et al.Defects in the human leukocyte antigen class Ⅰ antigen processing machinery in head and neck squamous cell carcinoma:association with clinical outcome.Clin Cancer Res,2005,11(7):2552-2560.

二级参考文献15

  • 1拉莱.苏祖克,彭玉华,周康,房新志,王莉.新疆不同民族子宫颈癌发病趋势分析[J].新疆医科大学学报,2006,29(7):569-571. 被引量：81
  • 2李连弟,鲁凤珠,张思维,牧人,孙秀娣,皇甫小梅,孙杰,周有尚,欧阳宁慧,饶克勤,陈育德,孙爱明,薛志福,夏毅.中国恶性肿瘤死亡率20年变化趋势和近期预测分析[J].中华肿瘤杂志,1997,19(1):3-9. 被引量：869
  • 3Yang BH,Bray FI,Parkin DM,et al.Cervical cancer as a priority for prevention in different world regions:an evaluation using years of life lost.Int J Cancer,2004,109(3):418-424.
  • 4Koopman LA,Corver WE,van der Slik AR,et al.Multiple genetic alterations cause frequent and heterogeneous human histocompatibility leukocyte antigen class Ⅰ loss in cervical cancer.J Exp Med,2000,191(6):961-976.
  • 5Chil A,Sikorski M,Bobek M,et al.Alterations in the expression of selected MHC antigens in premalignant lesions and squamous carcinomas of the uterine cervix.Acta Obstet Gynecol Scand,2003,82(12):1146-1152.
  • 6Mousonego J.HPV infections and cervical cancer prevention.Priorities and new directions.Highlights of EUROGIN 2004 International Expert Meeting,Nice,France,October 21-23,2004.Gynecol Oncol,2005,96(3):830-839.
  • 7Garrido F,Ruiz-Cabello F,Cabrera T,et al.Implications for immunosurveillance of altered HLA class Ⅰ phenotypes in human tumours,Immunol Today,1997,18(12):89-95.
  • 8Paulsson KM.Evolutionary and functional perspectives of the major histocompatibility complex class Ⅰ antigen-processing machinery.Cell Mol Life Sci,2004,61(19-20):2446-2460.
  • 9Zhang Y,Williams DB.Assembly of MHC class Ⅰ molecules within the endoplasmic reticulum.Immunol Bes,2006,35(1-2):151-162.
  • 10Seliger B,Ritz U,Ferrone S.Molecular mechanisms of HLA class Ⅰ antigen abnormalities following viral infection and transformation,Int J Cancer,2006,118(1):129-138.

共引文献17

同被引文献45

  • 1Shen YQ, Zhang JQ, Xia M, et al. Low-molecular-weight protein (LMP) 2/LMP7 abnormality underlies the downregulation of hu- man leukocyte antigen class I antigen in a hepatocellular carcino- ma cell line. J Gastroentercl Hepatol, 2007, 22(7 ) : 1155-1161.
  • 2Seliger B, Ritz U, Ferrone S. Molecular mechanisms of HLA class I antigen abnormalities following viral infection and transfor- mation. Int J Cancer, 2006, 118 (1) : 129-138.
  • 3Aptsiauri N, Cabrera T, Mendez R, et al. Role of altered expres- sion of HLA class I molecules in cancer progression. Adv Exp Med Biol, 2007, 601 : 123-131.
  • 4Bandoh N, Ogino T, Katayama A, et al. HLA class I antigen and transporter associated with antigen processing downregulation in metastatic lesions of head and neck squamous cell carcinoma as a marker of poor prognosis. Oncol Rep, 2010, 23 (4) : 933-939.
  • 5Ehrich M, Nelson MR, Stanssens P, et al. Quantitative high- throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry. PNAS, 2005, 102 ( 44 ) : 15785-15790.
  • 6Huang YW, Luo J, Weng YI, et al. Promoter hypermethylation of CIDEA, HAAO and RXFP3 associated with microsatellite in- stability in endometrial carcinomas. Gynecol Oncol, 2010, 117(2) : 239-247.
  • 7Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med, 2003, 349(21 ) : 2042-2054.
  • 8Paulin R, Grigg GW, Davey MW, et al. Urea improves efficiency of bisulphate -mediated sequencing of 5'-methylcytosine in genom- ic DNA. Nucleic Acids Res, 1998, 26(21) : 5009-5010.
  • 9Mehta AM, Jordanova ES, Kenter GG, et al. Association of anti- gen processing machinery and HLA class I defects with clinico- pathological outcome in cervical carcinoma. Cancer lmmunol Im- munother, 2008, 57(2) : 197-206.
  • 10Manning J, Indrova M, Lubyova B, et al. Induction of MHC class I molecule cell surface expression and epigenetic activation of antigen-processing machinery components in a murine model for human papilloma virus 16-associated tumours. Immunology, 2007, 123(2) : 218-227.

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中华病理学杂志
2010年 第10期

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