摘要
本文以多羟基笼型倍半硅氧烷(POSS-OH)为核,用辛酸亚锡催化丙交酯开环聚合,获得了无机/聚合物杂化星型聚乳酸(POSS-PLA),用其对海藻酸钠疏水改性合成了药物载体,采用布洛芬作为药物模型进行药物释放的研究。结果表明,改性海藻酸钠微球的包封率有一定提高,缓释效果明显。随着POSS-PLA在微球中含量增加,释放速率减缓,释放机制从一级释放逐渐向零级释放过渡。
Inorganic/polymer hybrid star polylactic acid（POSS-PLA） was obtained through ring-opening polymerization of lactide by using polyhydroxyl cage silsesquioxane（POSS-OH） as the core and tin（II） octoate as the catalyst.The star polylactic acid（POSS-PLA） was used to modify sodium alginate hydrophobically and a drug carrier was obtained.The drug release behavior was investigated by using ibuprofen as the model drug.The results showed that the drug loading rate could be improved and the release rate was postponed with an increase of POSS-PLA content in the carries.The release mechanism gradually changed from the first-order to the zero-order pattern after the modification.
出处
《药学学报》
CAS
CSCD
北大核心
2010年第11期1447-1451,共5页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(30970723)
关键词
药物载体
藻酸盐
星型聚乳酸
drug carrier
alginate
star polylactic acid
