摘要
简单介绍了生物化学的一个重要分支——酶动力学,它是研究酶催化反应速率的学科,着重回顾了酶动力学中的拟稳态假设的历史.拟稳态假设是一个提出来已超过80年的基本假设,几乎每一本生物化学方面的教科书在讲到酶动力学的时候都会对它进行详细讲解.该假设在分析酶动力学方程时有着重要的作用.许多实验结果、数值的模拟都显示了这一假设的正确性.然而,一直以来,有关拟稳态假设合理性和适用范围的理论研究却很少.最近,学界运用数学语言将这一假设严格地表述了出来,并且利用动力系统定性分析理论证明了这一假设是正确的.因此,将这一假设命名为拟稳态定律.
It was briefly introduced an important branch of biochemistry—enzyme kinetics,which was a subject of studying the rate of enzyme-catalyzed reactions.It was recalled the history of the assumption of quasi-steady state in enzyme kinetics.The quasi-steady state law in enzyme kinetics had been a basic assumption proposed more than 80 years ago,it was usually involved in detail in most biochemistry textbooks while introducing enzyme kinetics.The assumption played a key role in the analysis of enzyme kinetics equations.Many experiments,numerical simulations supported the validity of the assumption.However,it had rarely been theoretically discussed its reasonability and applicable range so far.The assumption was recently strictly expressed by means of mathematical language.The validity was then proved via qualitatively analysis of dynamic system.Therefore,the assumption could be named as quasi-steady state law.
出处
《浙江师范大学学报（自然科学版）》
CAS
2010年第4期361-368,共8页
Journal of Zhejiang Normal University:Natural Sciences
基金
国家自然科学基金资助项目(10771206)
中国973计划资助项目(2004CB318000)
关键词
酶动力学
拟稳态假设
拟稳态定律
enzyme kinetics
quasi-steady state assumption
quasi-steady state law
