摘要
目的检测帕金森病(PD)患者血清神经元特异性烯醇化酶(NSE)水平的变化,探讨多巴胺药物对PD患者神经细胞的作用。方法根据改良Webster将117例PD患者分为轻、中度症状组。轻度组随机分4组,给予不同剂量美多巴(SI^SIII组)及安慰剂(SIV对照组);中度组随机分6组,3组给予不同剂量美多巴(MI^MIII组),另3组在使用多巴药物基础上加用保护剂司来吉兰(MIV组)、溴隐亭(MV组)、吡贝地尔(MVI组)。在SI^SIII组和MI^MIII组停药3d以及加用美多巴后、SIV组停药3d以及加用安慰剂后、MIV^MVI组加用保护剂前后,分别测定空腹血清NSE浓度进行对比分析。结果轻度组血清NSE差异不明显(P(0.05),中度组在多巴胺达一定剂量后差异显著(P(0.05),不同保护剂在防止神经细胞损伤方面无显著性差异(P(0.05)。结论多巴胺对PD患者神经细胞的毒性作用可能与药物剂量有关。
Objective To measure the level of the neuron specific enolase（NSE） in the serum,and determine whether levodopa therapy has a toxic effect on nerve cells in patients with Parkinson′s disease（PD）.Methods According to the modified Webster scale,117 patients with PD were divided into the slight symptom group（S） and the moderate symptom group（M）.Group S was randomly subdivided into four groups： groups SI-SIII had madopar administered in different doses,and the control group SIV had a placebo administered.Group M was randomly subdivided into six treatment groups： the first three groups（groups MI-MIII） had madopar administered in different doses,after which dopamine was used,the other three groups（groups MIV-MVI） had three protectants： selegiline,bromocriptine and piribedil administered.The fasting serum NSE was determined 3 days after drug withdrawal（SI-IV,MI-MIII）,after madopar treatment（SI-III,MI-MIII）,after placebo administration（SIV）,before and after protectant administration（MIV-MVI）,and then the data were compared and analyzed.Results There was no statistical significance in the serum NSE level among slight symptom groups（P0.05）,while there was a statistical significance in moderate symptom groups when dopamine was increased to a high dose（P0.05）.Different protectants had no statistical significance in protecting nerve cells（P0.05）.Conclusion The toxic effect of dopamine on nerve cells may probably be associated with its doses.
出处
《山东大学学报（医学版）》
CAS
北大核心
2010年第10期69-72,共4页
Journal of Shandong University:Health Sciences
基金
山东省卫生厅资助项目(2001CA1CAAB6)
