摘要
目的:观察三乙醇胺乳膏在预防乳腺癌保留乳房术后同时推量调强放疗患者急性放射性皮炎中的作用。方法:选取101例2003-01-2010-03收治的早期乳腺癌保留乳房术后患者,分为预防组(52例)和对照组(49例)。预防组从放疗第1天预防性应用三乙醇胺乳膏涂抹照射野皮肤并>1cm的范围;对照组采用常规皮肤护理。结果:预防组Ⅰ、Ⅱ和Ⅲ度急性放射性皮炎的发生率分别为90.4%(47/52)、7.7%(4/52)和1.9%(1/52),对照组分别为69.4%(34/49)、24.5%(12/49)和6.1%(3/49),P=0.030。预防组≥Ⅱ度急性放射性皮炎的发生时间为21～36d,中位时间28d;对照组为14～35d,中位时间17d,P=0.006。放疗中断预防组2例,对照组8例,P=0.047。结论:三乙醇胺乳膏对早期乳腺癌保留乳房术后同时推量调强放疗所致的急性放射性皮炎有较好的预防效果,减轻了皮肤的急性放射性损伤,保障放疗计划顺利实施。
OBJECTIVE：To observe the clinical effect of Trolamine cream in preventing acute radioactive skin destruction of early breast carcinoma patients induced by simultaneous integrated boost intensity-modulated radiotherapy （SIB-IMRT）. METHODS： From Jan 2003 to Mar 2010, 101 patients undergoing SIB IMRT were enrolled. 52 patients were classified into the prevent group received a Trolamine cream application following the first radiotherapy, while the other 49, served as controls,who received no application of the cream, but only followed normal procedures of skin nursing. RESULTS： In prevent and control groups, the rates of grade I,II,III acute radiodermatitis occurred in 90.4%（47/52）,7.7%（4/52）,1.9%（1/52） and 69.4%（34/49）, 24.5%（12/49）, 6.1%（3/49）,respectively （P=0.030）. Concerning： of grade Ⅱ or over skin reaction, the occurring times were 21-36 days（median 28 days）in the prevent group and 14-35 days（median 17 days）in the control group （P=0.006）. The events of radiation interrupt were happened in 2 patients in the prevent group and 8 cases in the control group （P=0.047）. CONCLUSIONS： Trolamine cream can effectively reduce the acute SIB IMRT induced acute dermal injury for patients with early stage breast cancer. It can alleviate the patients’ suffering, and ensure radiotherapy plan implementation.
出处
《中华肿瘤防治杂志》
CAS
2010年第19期1579-1580,共2页
Chinese Journal of Cancer Prevention and Treatment
