摘要
目的探讨ＴＧＦβ１与ＴＧＦβＩ受体（ＲⅠ）在胃癌发生发展中的作用．方法采用免疫组化ＳＰ法检测基本正常胃粘膜（３０例）、肠化生（３０例）、不典型增生（２２例）及胃癌（２５例）中ＴＧＦβ１与ＴＧＦβＲⅠ的表达．结果肠化生、不典型增生及胃癌中ＴＧＦβ１的表达增强而ＴＧＦβＲⅠ表达递减（Ｐ＜００５）；不典型增生组与胃癌组间ＴＧＦβ１表达无显著差异（Ｐ＞００５）；１９例胃癌（７６％）ＴＧＦβＲⅠ表达缺失；ＴＧＦβ１与ＴＧＦβＲⅠ表达与胃癌的浸润深度及淋巴结转移无关，在癌周正常组织与正常粘膜组间亦无显著差异（Ｐ＜００５）．
AIM Evaluate the role of TGF β1 and TGF β R Ⅰ in the development and progress of gastric carcinoma. METHODS The expressions of TGF β1 and TGF β R Ⅰ in normal mucosa(30 cases), intestinal metaplasia(IM, 30 cases), dysplasia (Dys, 22 cases) and gastric adenocarcinoma(GAC, 25 cases) were detected by immunohistochemical techniques (SP). RESULTS In the IM, Dys and GAC tissues, the expressions of TGF β1 increased, while the expression of TGF β R Ⅰ decreased. The expression of TGF β 1 between Dys and GAC had no significant difference. No expression of TGF β R Ⅰ was detected in 19 cases of GAC(76%). The expressions of TGF β1 and TGF β R Ⅰ were not related to infiltration and lymph node metastasis of gastric carcinoma, and had no significant difference between normal mucosa near the carcinoma and normal controls. CONCLUSION TGF β R Ⅰ deletion and TGF β1 overexpression may be involved in the development of gastric carcinoma.
出处
《世界华人消化杂志》
CAS
1999年第6期507-509,共3页
World Chinese Journal of Digestology
关键词
转化生长因子
受体
胃肿瘤
癌前状态
transforming growth factor beta 1
receptor, transforming growth factor beta
precancerous conditions
stomach neoplasms
