摘要
目的探讨肠道病毒71型(EV71型)与其他肠道病毒所致手足口病的神经系统临床特征的差异。方法收集106例手足口病患儿的临床资料,根据病原学检查结果分三组:EV71感染组,柯萨奇病毒A16组(CA16组)、其他肠道病毒感染组(其他组),比较3组在神经系统感染发生率、发热、皮疹、神经、呼吸、循环系统表现和实验室检查方面的差异。结果 EV71感染组63例,CA16组16例,其他病毒组27例。神经系统感染发生率EV71感染组高于其他两组(P<0.05);EV71感染组较CA16感染组热程长、体温峰值高(P<0.05);EV71感染组颤抖的发生率高于CA16感染组,头痛、呕吐、抽搐的发生率低于CA16感染组,颤抖、惊跳的发生率高于其他肠道病毒感染组;实验室检查指标三组差异无统计学意义(P>0.01)。结论 EV71型所致手足口病与其他肠道病毒所致手足口病比较热程更长,体温更高,更容易累及神经系统及导致危重症,颤抖、惊跳症状的发生率更高。
Objectives To understand the difference of clinical features of hand-foot-mouth disease（HFMD） caused by enterovirus 71 and other enterovirus types.Methods A total of 106 children with HFMD were included and divided into three groups according to etiology： group 1（enterovirus 71 infection,n = 63）,group 2（Coxsackievirus A16 infection,n = 16） and group 3（other enterovirus types infection,n = 27）.The information of fever,rash and clinical manifestations of nervous system,respiratory and circulatory systems,and the laboratory data were summarized and analyzed among the three groups.Results The patients in group 1 had higher incidence of central nervous system infection than that of group 2 and group 3.The patients in group 1 had higher peak temperature,longer fever time and more frequent limb tremor and irritation than that in group 2（P 0.05）.The patients of CA16 had higher incidence of headache,vomiting,convulsion than that in group 1（P 0.05）.Conclusions Patients with EV71 infection had higher peak temperature,longer fever time,higher incidence of central nervous system infection,more frequent limb tremor and irritation than other enterovirus types infection.These characteristics may help pediatricians to identify the type of enterovirus.
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2010年第11期1011-1014,共4页
Journal of Clinical Pediatrics
关键词
手足口病
肠道病毒7l型
儿童
神经系统症状
hand-foot-mouth disease
enterovirus 71
children
nervous system manifestations
