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静脉全麻对脑胶质细胞瘤患者IL-2和sIL-2R的影响

The Influence of Total Intravenous General Anesthesia on Interleukin-2 and Soluble Interleukin-2 Receptor in Patients with Cerebral Glioma
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摘要 目的:探讨静脉全麻对脑胶质细胞瘤开颅手术患者白细胞介素-2(IL-2)和可溶性白细胞介素-2受体(sIL-2R)的影响意义。方法:选择天坛医院神经外科择期脑胶质细胞瘤开颅切除术患者21例。检测麻醉前,麻醉诱导后,手术结束时,术后2h的血清IL-2及sIL-2R浓度。结果:IL-2浓度在麻醉诱导后、手术结束时和术后2h均较麻醉前明显降低(P<0.05)。麻醉诱导后sIL-2R浓度较麻醉前有所升高,但差异无统计学意义(P>0.05),手术结束时和术后2h的sIL-2R浓度明显低于麻醉前(P<0.05)。结论:静脉麻醉与手术对脑胶质细胞瘤患者免疫功能有抑制作用。 Objective: To investigate the influence of total intravenous general anesthesia on serum interleukin-2 (IL-2) and soluble interleukin-2 receptor (slL-2R) in patients with cerebral glioma craniotomy. Methods: In twenty-one cerebral glioma craniotomy patients, serum IL-2 and slL-2R were measured before anesthesia, after induction of anesthesia, at the end of operation, and at the 2h after operation. Results: Serum IL-2 concentration decreased significantly after induction of anesthesia, at the end of operation and at the 2h after operation comparing with the IL-2 level before anesthesia( P 〈0.05 ). Serum slL-2R coneentration after induction of anesthesia increased little than that before anesthesia( P 〉 0.05 ). Serum slL-2R concentration at the end of operation and 2h after operation decreased significantly than that before anesthesia( P 〈 0.05 ). Conclusion: Total intravenous general anesthesia and operation inhibited immune functions of patients with cerebral glioma.
出处 《肿瘤预防与治疗》 2010年第3期214-215,227,共3页 Journal of Cancer Control And Treatment
基金 天坛医院青年科研基金(2008-03)
关键词 静脉全麻 脑胶质细胞瘤 IL-2 SIL-2R Total Intravenous General Anesthesia Cerebral Glioma IL- 2 slL- 2R
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