摘要
目的评价托烷司琼不同时间给药对腰硬联合麻醉下肛肠科手术术中和术后恶心、呕吐的预防效果。方法择期肛肠科手术患者80例,ASAⅠ～Ⅱ级,随机分为4组,每组20例。对照组(C组)不给予托烷司琼;托烷司琼术前组(Ⅰ组),于腰麻成功后静脉注射(静注)托烷司琼5 mg;托烷司琼术前和术后联合用药组(Ⅱ组),于腰麻成功后静注托烷司琼2 mg,术毕静注托烷司琼3 mg;托烷司琼术后组(Ⅲ组),于术毕静注托烷司琼5 mg。观察各组术中和术后24 h恶心、呕吐发生情况,并记录有无过度镇静及锥体外系反应等不良反应的发生。结果与C组比较,Ⅰ、Ⅱ组术中恶心及呕吐发生情况明显改善(P<0.05)。与C组比较,Ⅰ、Ⅱ和Ⅲ组术后恶心及呕吐发生情况改善明显(P<0.05),Ⅱ、Ⅲ组恶心及呕吐发生率低于Ⅰ组,差异具有显著意义(P<0.05)。4组均无过度镇静及锥体外系反应发生。结论托烷司琼术前和术后联合给药能明显减少腰硬联合麻醉下肛肠科手术患者恶心、呕吐的发生。
AIM To observe the effects of administration of tropisetron at different time to prevent intraoperative and postoperative nausea and vomiting（IONV and PONV）of anorectum surgery under the combined spinal and epidural anesthesia（CSEA）.METHODS Eighty patients scheduled for anorectum surgery with CSEA were randomly divided into four groups,20 in each.The patients in the group C were not administered tropisetron.The patients in the groupⅠwere administered tropisetron 5 mg by intravenous after anesthesia.The patients in the groupⅡwere administered tropisetron 2 mg by intravenous after anesthesia and 3 mg after the operation.In groupⅢ,the patients were administered tropisetron 5 mg by intravenous after the operation.The occurrences of nausea and vomiting during operation and 24 hours after operation were observed.RESULTS Compared with the group C,the incidences of IONV were significantly lower in the groupⅠandⅡ,and the incidences of PONV were significantly lower in the groupⅠ,Ⅱand Ⅲ（P 0.05）.The incidences of PONV in the group Ⅱ and Ⅲ were significantly lower than that in the groupⅠ（P 0.05）.No over sedation and extrapyramidal symptoms occurred in four groups.CONCLUSION Preoperative and postoperative adminis-tration of tropisetron can effectively reduce the occurrence of nausea and vomiting.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2010年第11期876-878,共3页
Chinese Journal of New Drugs and Clinical Remedies
关键词
托烷司琼
恶心
呕吐
麻醉
tropisetron nausea vomiting anesthesia
